The Effectiveness Of Neo-adjuvant Chemotherapy In 87 Xinjiang Uighur Females With Breast Cancer

Objective:To assess the influencing factors of response to neoadjuvant chemothera-py (NAC) in Xinjiang Uighur females with breast cancer. Methods:The clinical data of 8 7 Xin-jiang Uighur females with breast cancer undergoing NAC from January 2010 to Ju-ne 2014 were retrospectively studied. Estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER-2), proliferation index of Ki-67 were in-vestigated by immunohistochemistry. The role of age, menopausal status, body mass index (BMI), tumor size, axillary lymph node status, clinical stage, number of NAC cycles, mo-lecular subtype for evaluating pathological complete response (pCR) rate and clinical effe-ctive rate [complete response (CR)+partial response (PR)] were analyzed. Results:After NAC, the total clinical effctive rate (CR+PR) was 85.06%(74/87), with stable disease (SD) rate of 11.49%(10/87), progressive disease (PD) rate of 3.45%(3/87), pCR rate of 14.9 4%(13/87). The patients with HR negative, high Ki-67 index (>20%), BMI<25 kg/m2, NAC cycles>4 cycles are more sensitive to NAC. NAC cycles>4 cycles was an indepe-ndent factor for predicting pCR after NAC (P=0.004, OR=0.081; 95%CI:0.015-0.441). Conclusion:Hormone receptor negative, high Ki-67 index, BMI<25 kg/m2 have a high-er clinical effective rate (CR+PR). Hormone receptor negative, NAC cycles>4 cycles ha-ve a higher pCR rate. NAC cycles> 4 cycles is an independent factor for predicting pCR a-fter NAC.