| Objective To investigate the curative effect and safety of decitabine combined with CAG regimen treatment for elderly acute myeloid leukemia(AML)patients.Method A total of 76 cases of elderly patients with acute myeloid leukemia were divided into two groups, of which 46 patients received decitabine combined with CAG chemotherapy regimens as the observation group, 30 patients received routine CAG chemotherapy treatment as the control group.The efficacy and adverse reactions were compared after two courses of chemotherapy.Results Both two groups had certain curative effect in the treatment of acute elderly myeloid leukemia. The total effective rates and complete remission rates of the decitabine combined with CAG chemotherapy regimens group were significantly higher than those of the CAG chemotherapy treatment group, the differences had statistics meaning(P<0.05). Comparing the efficient and remission rates of acute elderly myeloid leukemia related with MDS in the observation group with those of AML not related with MDS, the difference didn’t have statistically significant(P>0.05). During the chemotherapy, the incidences of adverse reactions such as pulmonary infection, gastrointestinal tract reaction and fever in the observateion group were higher than those in control group, the differences had statistics meaning(χ2 =4.447ã€4.308ã€4.308,P <0.05). While the incidence of thrombocytopenia was lower than that in control group, which also had statistically significant(χ2 =9.206, P < 0.05). In the combination group, lung infection rate was positively correlated with age(r = 0.906,P < 0.05).Conclusion Decitabine combined with CAG chemotherapy regimens has a good curative effect on the elderly acute myeloid leukemia. At the same time, incidents of pulmonary infection,nausea and vomiting increase obviously. Some old people can not be tolerated, especially in aged patients. So we should be careful when use the scheme. |
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