| Objective:In recent years,as changing the way of living standard and life behavior,detection rate of hyperuricemia(HUA) is rising year by year.Hyperuricemia is not only associated with gout,but blood sugar,blood fat,blood pressure disorder and abnormal renal function.This thesis was done to investigate the relationship between metabolic diseases,dietary factors and hyperuricemia in ethnic minority adults, It provides dietary guidelines on how to prevent the occurrence of gout and its complicationand,also to study the relationship between interleukin-1(IL-1) and HUA.It provides guidance for preventing and controlling chronic diseases.Methods: Qualified medical data of 12808 cases was collected using randomized cluster sampling method from two hospital in Duyun,Guizhou from January 2014 to December 2014.Meanwhile,100 cases of Buyi, Miao and Han adults who had been diagnosed with HUA were chosen respectively as the case group.100 cases of normal serum uric acid levels from each of the three ethnic groups were selected as the control group. A survey was conducted to collect their basic information, lifestyle, diet, physical measurements, biochemical parameters,etc. IL-1 was determined by enzyme linked immunosorbent assay( ELISA). Results:(1) The medical information of 12808 cases were gathered, there are 3081 cases of HUA at a percentage of 24.06%.2701 out of 7837 males were diagnosed with HUA(34.47%), and 380 out of 4971 females with HUA(7.64%).The occurrence of HUA in males was found significantly higher than in females(P=0.000).(2)Results showed that the concentration of serum urinc acid increased as the age increased in females. But the concentration of serum urinc acid did not increased as the age increased in males.(3) Correlation analysis was completed to evaluate the relationship between biochemical parameters and serum uric acid level.It was found that the content of uric acid was positively correlated with diastolic blood pressure, triglycerides and creatinine,body mass index,low-density lipoprotein. serum uric acid was negatively correlated with VI the content of high-density lipoprotein and fasting plasma glucose.(4)There were significant differences in SBP,DBP,BMI,BUN,CREA, TG,HDL,LDL,FPG between the HUA group and the normal group(P<0.05). Furthermore,The detection rates of hypertension,hyperglycemia,overweight or obesity and hypertriglyceridemia in the case group were higher than control group.(5) In Buyi group and Miao group, the levels of SUA,SBP,DBP,CHOL,TG,CREA,abdominal perimeter,BMI in case group were significantly different from the controls(P<0.05).In Han group,the SUA,DBP, CHOL,TG,CREA,BMI were significantly different from the controls( P <0.05).(6)Correlation analysis was conducted with the serum uric acid levels and the biochemical parameters. The results showed that creatinine,LDL,abdominal circumference were positively correlated with the levels of uric acid; fasting glucose and HDL were negatively correlated with the levels of uric acid.(7)Case control study showed that hypertension and fatty liver were associated with HUA in Buyi group; fatty liver and gout in Miao group; hyperlipidemia,fatty liver and gout in Han group.(8)The diet comparison between the case group and the control group showed that there were significantly difference in consumption of wine and beer, and the frequency of eating at home.(9)Binary logistic regression analysis was performed to explore the impact of diet on serum uric acid.Results showed that there was a correlation between the consumption of grains, animal offal,fish,milk,red sour soup,mushrooms,alcohol and blood uric acid levels(P <0.05).(10)The results of logistic regression analysis in three ethnic groups showed that there was a correlation between the level of serum uric acid and the consumption of steamed bread, red sour soup,poultry,tea,and wine in Buyi population; grain,vegetable,sour soup,animal offal and milk in Miao group; tofu, red sour soup,tea,red wine,rice wine and sweet beverage in Han group(P <0.05).(11) Food consumption monthly comparative analysis was performed in the three ethnic groups.The results showed that there were significantly difference of consumption of steamed bread,grains, animal offal,seafood,pickled food,red sour soup,white sour soup,beer between the case group and the control group in Buyi group.The consumption of fried foods, animal offal,seafood,fish,eggs,milk,tea, liquor,beer,wine were significantly different between the case group and the control group in Miao group. In Han group,significant differences were found between the case and the control groups in the consumption of whole grains,poultry, animal offal, vegetables and fruits,mushroom,vegetables sour soup,wine and beer.(12)IL-1 levels in case group were found significantly different from the control group..IL-1 levels were positively correlated with the contents of creatinine,uric acid and BMI. Conclusions:The detection rate of HUA is relatively high among the adults from the south of Guizhou,China.Higher rates are found in males than in females.HUA is found associated with hypertension, high triglycerides and other metabolic abnormalities.Eating steamed bread,grains and drinking red sour soup prevents people from having HUA.On the contrary,eating poultry meat, animal offal, and alcohols will put people at the risk of having HUA.In addition,there are differences in the food styles inducing HUA in the three different ethnic populations.For instance,it’s mainly the animal offal which induce HUA in Buyi population,rice wine in Miao population and liquor in Han population. IL-1 level of HUA group is higher than the control group, uric acid level is a strong factor to influence IL-1. |
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