| Research Objective:Transdermal drug delivery technology has a long history in our country,which is a method by using skin、 mucosa as the carrier to import drugs through the skin at a certain rate,and after capillary absorption,to send the drugs to the systemic circulation to play the efficacy.It has some advantages such as no liver first-pass effect、constant effective blood drug concentration、convenient clinical application and so on.The Chinese medicine Large Chengqi Decoction,as the first choice for the gastrointestinal obstruction after operation,has Tongli、clearing heat、promoting blood circulation、clearing the hot tubercle and other functions,combining the gel patch which is rich in Large Chengqi Decoction(Weichangning patch) with ultrasound for patients with postoperative obstruction of colorectal tumor,to observe the effect on promoting the bowel function recovery with postoperative obstruction of colorectal tumors,and to evaluate the safety of ultrasound conductivity treatment instrument.Subjects and Methods: The research object:Total 110 patients with postoperative obstruction of colorectal tumors in the first hospital of Jilin University、the second hospital of Jilin University、the China-Japan Union Hospital of Jilin University and the XinMin branch of the third hospital of Jilin University were collected from January 2014 to February 2015,with 55 cases in the treatment group and 55 cases in the control group; among them there were 59 male and 51 female; the average age of the control group was 55.69±4.38, and the average age of the treatment group was 55.09±4.04; there were 62 cases of rectal cancer and 49 cases of colon cancer,all of them were performed colorectal radical resection or partial resection in the general anesthesia. No significant differences were found between the two groups in age, gender, disease and other aspects(P > 0.05), which showed that the treatment group and the control group had good balance in gender,age,diagnosis, operation mode and so on, which was comparable.2.The test scheme:According to the admitted sequence,the patients were randomly divided into treatment group and control group with 55 cases in each group, and were given conventional surgical therapy immediately when accepted into group. Control group: were given fasting, gastrointestinal decompression、total parenteral nutrition、water and electron supplement, acidosis、low potassium and other electron disorder were correctted, and proton pump inhibitor treatment was applied, and the patients were encouraged ambulation、massage the abdomen to promote the bowel peristalsis. Treatment group: in addition to conventional surgical treatment,were given the ultrasound provided by Beijing Noah TongZhou Technology Limited company with the Weichangning patch containing Chinese medicine Dachengqi Decoction once a day with 30 minutes each time, and after treatment the Weichangning patch was kept 40 minutes.(note, two groups were treated with same intravenous therapy); we observed the treatment group and the control group with the first anal exhaust time、the first defecation time; abdominal pain, abdominal distention disappearance time; bowel sound recovery time; abdominal circumference changes; and simultaneously recorded the biochemical indexes and the vital signs. All the indicators were statistically analysed with SPSS 19.0 statistical software package. Statistical analysis methods: SPSS19.0 software was used, the measurement data was expressed with the mean±standard deviation( x ±s)by t test; the enumeration data was analysed by X2 test, p<0.05 as the statistical significance.Research results: The postoperative bowel sound recovery time of the treatment group and control group was 42.836±5.301and46.5 ±7.501,and the first anal exhaust time of the two groups was98.60±10.62 and 116.34±11.87, the first defecation time of the two groups was123.89±13.88 and 144.96±15.6, the two groups was statistically significant difference in. The abdominal circumference changes was statistically significant between the two groups(P<0.05); no significant differences were found between the two groups in the vital signs(P >0.05); no significant differences were found between the two groups after treatment in the blood and urine routine, hepatic and renal function, electrocardiogram examination(P >0.05), no statistically significant difference(P>0.05),three patients in the treatment group using ultrasound had local swelling phenomenon but no blisters, there was no statistical significance when analysed(P>0.05).Research conclusion: Target transdermal Weichangning patch containing Chinese medicine Large Chengqi by ultrasound can accelerate the gastrointestinal function recovery with postoperative obstruction of colorectal tumors,and reduce the incidence of abdominal distension and abdominal pain, which is safe and effective in clinic. |
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