The Correlation Between Vitamin And Nutritional Anemia In The Chinese Population: A Meta-analysis

Objective To quantify the correlation between vitamin B12、folic acid vitamin A and nutritional anemia in Chinese population. Methods Meta-analysis was performed by using Stata12.0. Seventeen electronic databases of case-control studies from January 1959 to March 2015 were systematically searched on the basis of the published studies evaluating the correlation between vitamin B12、folic acid、vitamin A and nutritional anemia. A total of 5514 cases person and control of 15276 were enrolled in the under study. Cochrane’s Q and I2 statistics were used to evaluate heterogeneity among studies and standardized mean difference(SMD) were calculated using random-effects models. And publication bias was also calculated by funnel plot, Egger linear regression test and Begg rank correlation test. Results There exists discrepancy between megaloblastic anemia group and control group at the level of serum vitamin B12(Z=5.86, P=0.000).There exists discrepancy between megaloblastic anemia group and control group at the level of serum folic acid(Z=5.58,P=0.000). There exists discrepancy between anemia group and control group at the level of serum vitamin A(Z=5.28, P=0.000). Conclusion The levels of vitamin serum B12 and folic acid are straightly related to megaloblastic anemia. Either or both of vitamin B12 and folic acid deficiencies induce megaloblastic anemia. The levels of serum vitamin A are straightly related to nutritional anemia. Vitamin A deficiency induces nutritional anemia.