A Study On The Correlation Between Spleen/residual Liver Volume Ratio And Hepatic Function After Hepatic Resection

Objective:To investigate the association between the spleen/residual liver volume ratio and hepatic function after hepatic resection. To measure the volumes of residual liver and spleen after primary liver cancer resection using 3D reconstruction software IQQA-Liver(USA EDDA company) and water intrusion measurement, to calculate the spleen/residual liver volume ratio, to analyze the association between the spleen/residual liver volume ratio and postoperative hepatic function, to understand the impact of the spleen/residual liver volume ratio on postoperative hepatic function, to provide guidance for clinicians to accurately assess the postoperative hepatic function before surgery and to prevent the occurrence of liver failure after liver resection.Method:A retrospective analysis was performed on a total of 57 patients diagnosed with primary liver cancer and operated in our department from February 2012 to June 2013. The volumes of residual liver and spleen were measured after primary liver resection using 3D reconstruction software IQQA-Liver and water intrusion measurement, the spleen/residual liver volume ratio was calculated, and the association between the spleen/residual liver volume ratio and postoperative hepatic function as well as length of hospitalization.Results:Multiple regression analysis showed association between the score Child-Pugh of postoperative and the spleen/residual liver volume ratio.the score was lower when the spleen/residual liver volume ratio was smaller(t=7.731, P≈0.000),i.e.liver function was better. When the spleen/residual liver volume ratio≤0.9, the median hospital stay was 13d(11～15d); whereas when the volume ratio>0.9, the median hospital stay was 21d(14～28d). There was a statistically significant difference between the two subgroups in the length of hospitalization (P=0.000)Conclusion:The spleen/residual liver volume ratio can effectively predict postoperative hepatic function. A detailed preoperative surgical plan should be developed, to estimate the residual liver volume (spleen/residual liver volume ratio≤0.9),to minimize the risk of surgery, and to reduce the occurrence of liver dysfunction after surgery.