Experimental Study Of The Relationship Between The Relationship Between The Content Of SDF-1 In Different Period Of Myocardial Infarction And Left Ventricule Function

Objective:To investigate the relationship between the content of SDF-1 in myocardium after myocardial infarction in different period and left ventricular function. Methods:23 Chinese miniature pigs were randomly divided into the experimental group and the control group. The swines in experimental group were prepared as acute myocardial infarction model by ligating anterior descending coronary artery and were randomly divided into 6 subgroups according to the different time points after infarction. The Left ventricular end-diastolic diameter (LVDd), left ventricular ejection fraction (LVEF) and left ventricular short axis shortening rate (LVFS) were measured respectively. Global circumferential strain (GCS) and the radial strain (GRS) of left ventricle were both measured. The content of SDF-1 were also measured by real-time quantitative PCR. Results:Compared with the control group, SDF-1 levels were significantly elevated, and LVEF, LVFS and GRS were reduced. However, LVEDd were significantly increased. The content of SDF-1 and GCS has a negative correlation (r=-0.580, P=0.000). Conclusions:The content of SDF-1 in myocardial tissue have a certain relationship with GCS of left ventricular myocardium.