| Objective:Through a retrospective clinical study, compared with the observation group, observe the median survival time and clinical benefit (including the change of the tumor, Karnofsky score, clinical symptoms and immune function) of Qi Yin deficiency of advanced non-small cell lung cancer (NSCLC) patients of the Feiliuping ointment maintenance treatment. To provide clinical basis for the further study of Feiliuping ointment on the efficacy of maintenance therapy.MethodA retrospective analysis of Qi Yin deficiency type advanced NSCLC Inpatient cases who completed 4-6 cycles of observation from January 1,2009 to January 30, 2015,with good curative effect evaluation was made. Take patients who took Feiliuping ointment as maintenance treatment into Feiliuping ointment group, and take observation group as comparison.We collected 90 cases, and 76 cases of them match standards, including Feiliuping ointment group 36 cases,40 cases of observation group. follow up by telephone, analyse the survival of the two groups of patients and comparison of clinical benefit between two groups were made.Result1 Two groups survival were compared by log-rank. the survival curve shows that MST value for Feiliuping ointment group is 11 months/while observation group 8 months and total patients 9 months.The survival time of two groups by chi square test, Log Rank (Mantel-Cox), P=0.053, the difference was not statistically significant;2 Among the gender, age, pathological type, clinical stage, primary site, multi factor COX regression analysis of the operation situation, survivalcurve and P value by using Kaplan-Meier method show that the clinical stage P=0.015, (P<0.05), with statistical significance while gender, age, pathological type, clinical stage,primary site P>0.05, the difference was not statistically significant.3 Clinical benefit3.1 According to the clinical evaluation,among 36 patients of Feiliuping ointment group, there are 0 CR patients,1 PR,28 SD,7 PD, the total effective rate of CR+PR patients was 2.8%, and the disease control rate of CR+PR+SD was 80.6%.In observation group, there are 0 CR patients,0 PR,23 SD,17 PD, the total effective rate of CR+PR was 0%, the disease control rate of CR+PR+SD was 57.5%. Chi square test of the efficacy shows that X2,=5.461, P=0.065, P>0.05, the difference was not statistically significant.3.2 T test of TCM syndrome score of the two groups after treatment shows that P<0.05,clinical syndromes of the two groups have significant difference. The score of Feiliuping ointment group was deregulated from 17.1+2.4 before treatment to 9.2+1.5 after treatment, and the observation group from 16.2+2.8 to 13.6+ 2.3. The paired t test shows t=-1.03, P=0.021<0.05. showed a statistically significant difference between two groups of clinical symptoms before and after contrast. Among 36 patients of the Feiliuping ointment group,3 cases significantly improved,19 cases partly improved,14 cases no improvement, the total efficiency was 52.8%.observation group,40 patients,0 significant improved cases,11 partly improvement cases,29 cases no improvement, the total efficiency was 27.5%. Chi square test shows X2=10.184,P=0.006, the difference was statistically significant.3.3 In the Feiliuping ointment group, Karnofsky score rose from 68.7± 7.3 before treatment to 79.4±6.1 after treatment, while observation group dropped from 70.1±8.0 to 80.5 ±7.4. Paired t test between two groups shows P=0.057, changes have no significant difference after treatment. In the Feiliuping cases,16 effective,10 ineffective; while in observation group,1 markedly effective,9 effective,20 ineffective.The chisquare test shows X2=5.654, P=0.059, the difference was not statistically significant3.4 Immune function3.4.1 the all immune indexes before treatment of the two groups by t test (P>0.05) which shows without any difference. The result indicates the baseline before treatment was stable.3.4.2 The immune indicators compare before treatment with figures after in the Feiliuping ointment maintenance treatment group, besides CD8+,(P>0.05)the other indicators differences were statistically significant. Among the indicators with statistically significance,in addition to the trend of Treg was decline,the otherstrend was rising.3.4.3 The immune indicators compare before treatment with figures after in the observation group. All the indicators show the difference were not statistically significant.3.4.4 Focus on the immune indicators after treatment, compares the Feiliuping ointment maintenance treatment group and the observation group,all the indicators show the difference were statistically significant besides CD8+(P>0.05)..To analyze from the average level of the groups with statistically significance,all indicators average level of the Feiliuping ointment maintenance treatment group was higher than the observation group in addition to the Treg.3.4.5 In the evaluation of the patients immune function Feiliuping ointment maintenance treatment group contains 4 markedly effective cases,16 effective cases and 16 ineffective cases, the total efficiency was 55.6%, observation group, contains 0 markedly effective cases,8 effective cases and 32 ineffective cases, the total efficiency is 12.5%, The chi square test shows X2=10.714, P=0.005, the difference was statistically significant.Conclusion:1 Feiliuping ointment maintenance treatment has the advangtage in improving the MST of the terminal NSCLC patients which were defined with deficiency of Qi and Yin. Among the relevant indicators affect the survival time, the clinical stage may be the independent prognostic factors.2 For the terminal NSCLC patients which were defined with deficiency of Qi and Yin., Feiliuping ointment maintenance treatment shows certain curative effect in the aspect of the improvement of clinical symptoms and immune function within the clinical benefit. |
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