The Effect Of Losartan Combined With Metoprolol In The Treatment For Senile Patients With Severe Heart Failure

Objective:To investigate the clinical effect of losartan combined with metoprolol in the treatment for senile patients with severe heart failure. Methods:Choose 60 cases of senile patients with severe heart failure in our hospital during January 2010 to January 2013,which were randomly divided into three groups by using random number table method:losartan with metoprolol therapy group,losartan therapy group and control group, each group has 20 patients. All patients were treated with routine, the control group use oral cardiac and diuretic, the chlorine therapy group take chlorine and the losartan with metoprolol therapy group take losartan and metoprolol.Detected the cardiac function,left ventricular ejection fraction (LVEF) and b-type brain natriuretic peptide (BNP) in 0.5A, 1.0A before and after the treatment and observed the clinical effect 1.0a after treatment.Results:The cardiac function,left ventricular ejection fraction (LVEF) and b-type brain natriuretic peptide (BNP) has no significant statistical differences among three groups before therapy(P>0.05); The cardiac function and BNP of the losartan with metoprolol therapy group and the losartan therapy group after 0.5a and 1.0a were lower than control group, while LVEF was higher than control group(P<0.05); The cardiac function,LVEF and BNP after 0.5a between the losartan with metoprolol therapy group and the losartan therapy group has no significant statistical differences(P>0.05); The mortality rate among these three groups after 1.0a has statistical differences(.P>0.05);The losartan with metoprolol therapy group has the least amount of annual average hospital ization times and such confinement,fol lowed by losartan therapy group.Conclusion:Better effect is achieved by losartan combined with metoprolol in the treatment for senile patients with severe heart failure.