Magnetic Resonance Imaging Evaluate The Effect Of Neoadjuvant Chemotherapy For Breast Cancer

Objective:To evaluate the breast cancer after neoadjuvant chemotherapy of MR dynamic enhancement characteristics of the changes of hemodynamics, provide more evidence for evaluation of curative effect and prognosis of neoadjuvant chemotherapy. Methods; Select confirmed by pathology biopsy puncture and receiving neoadjuvant chemotherapy of 50 patients with advanced breast cancer. To calculated respectively the tumor regression rate, the changes of ADC values and the time signal intensity curve (TIC) before and after chemotherapy. All patients underwent surgery after chemotherapy treatment, In accordance with the final pathology results, divided into complete remission group(MHR) and uncomplete remission group(NMHR). With post operative pathology reactive classification as the gold standard, the ROC analysis, calculate cancer △LD% and ADC values of neoadjuvant chemotherapy pathologicalarea under ROC curve of reactive assessment, and to assess the diagnosis of MHR and NMHR cut-off point. Results:Postoperative pathology reactive classification MHR in 19 cases, the total of NMHR is 31 cases. From 25 patients with TIC Ⅲ/Ⅱ into Ⅱ/Ⅰ,15 cases remained unchanged,10 cases from Ⅱ type into Ⅲ type. DeltaALD% and ADC values respectively using independent sample t-test, differences bet-ween the two groups was statistically significant(P<0.05). The postoperative patholog-ical reactive classification as the gold standard, the ROC analysis, the △LD% ROC area under the curve is 0.882, Pick truncation points according to the principles of statistics, LD%>52.3%, the sensitivity was 68.4%, specificity of 83.9%; the ADC value-s are under the ROC curve is 0.933. ADC values>74.5%, the sensitivity was 84.2%, specificity of 90.3%. Conclusion:Breast cancer before and after neoadjuvant chemotherapy, TIC is given priority to with Ⅲ type; Lump withdrawal rate and the change of the ADC values can better predict the tumor pathological reaction after chemotherapy, and the change of ADC value is earlier than morphological.