The Role Of Atrovastatin On Endothelial Function And Circulating Endothelial Progenitor Cells In Patients With Coronary Slow Flow

Objective: To observe the effects of atorvastatin in patients with coronary slow flow(CSF) by lipid parameter,inflammation markers,endothelial function,cell count and function of peripheral circulating endothelial progenitor cells(c EPCs).To explore the relationship between c EPCs and the nosogenesis of CSF by means of evaluate how atorvastatin impact on endothelial function,cell count and function of c EPCs from patients with CSF.Methods :The corrected TIMI frame count(CTFC) was used to evaluate coronary flow rates.A total of 100 patients with coronary slow flow by underwent coronary angiography(CAG) because of chest pain to exclude of suspected coronary heart disease.Those patients were randomly divided into atorvastatin treatment group(50 samples) and conventional therapy group(50 samples).Statin treatment group received atorvastatin 40 mg for 4 weeks on the basic of conventional therapy, the conventional therapy group only received conventional therapy.Another 50 patients were selected as normal control groupwho suffered chest pain but the results of CAG came out normal.Serum ET-1 and IL-6 level were measured by ELISA.Serum NO was detected by chromatometry.The number and funtion of c EPCs in CSF patients were detected before and after treatment.Results: After treatment, the TC, LDL-C, TG level of statin treatment group were significantly reduced.The NO, ET-l, IL-6 levels of Statin therapy group were significantly improved.Atorvastatin could significantly increase CSF patients’ c EPCs number, and improved the adhesion, migration and proliferation ability of c EPCs.Conclusions: Taking short-term intensive atorvastatin improves coronary endothelial function in patients with coronary slow flow.The intensive atorvastatin treatment can increase the number of c EPCs in patient with CSF while couple with c EPCs function improved.