Synthesis Of Isoxazoline

This paper mainly discusses the synthesis of lsoxazoline compounds, The dissertation can be mainly described as the following three parts: 1. We design palladium catalytic 5-exo cyclization reaction to afford 5-methyl isoxazoline compounds by unsaturated oxime, to solve the traditional reaction facing poor functional group compatibility and regioselectivity problems. At the same time, we further study the way of β-H elimination that two ways can be carried out depending on non activated olefin lateral substituents; finally we also do related research in application value of the reaction in drug synthesis that we successfully synthesized valdecoxiband oxacillin. 2. We are using Pd/Cu X2(X = Cl, BR) system successfully afford 5- chlorine(bromine) isoxazoline compounds. This reaction condition is mild, the yield is high, and it is suitable for a wide range, and the related studies of its derivatization biochemistry are related.. 3. Fluoride compounds are widely used in pharmaceutical, agricultural and polymer materials, and the development of fluoride is of great significance for the synthesis of fluoride.. We use free radical reaction successful synthesis of a series of containing fluorine isoxazoline compounds.The short board that has no one to synthesize the fluorine isoxazoline compounds is added, and the mechanism of the synthesis is proved.In summary, we found some simple and convenient ways to the synthesis of isoxazoline moiety and which had been applied to the next transformation. They’re not only new methods for the synthesis of isoxazoline moiety, but also have prospect in application of organic synthesis and fluorinated drug.