Epidemiological And Etiological Characteristics Research Of Hand, Foot And Mouth Disease In Liaocheng In 2012 To 2014

[Background]HFMD is a common infectious disease caused by a viral infection of the intestine, from the 1996 foot and mouth disease since the outbreak of many in our country, critically ill patients with acute infection, and some even life-threatening. Liaocheng appeared in recent years, the prevalence of foot and mouth disease in Shandong province in multiple cities, high social concern, causing the party and the government as well as the attention of the medical sector, research Liaocheng characteristics of foot and mouth disease and etiology, epidemiology Science has become urgent problem to be solved.[Research purposes]1. Analysis of 2012～2014 Liaocheng epidemiological characteristics of foot and mouth disease, the study population distribution and time distribution and geographical distribution, provide the basis for prevention and control of foot and mouth disease.2. Laboratory studies Liaocheng HFMD pathogen composition, strain analysis Liaocheng local advantages and critically ill patients with type virus strains.3. The use of molecular biology, Liaocheng HFMD EV71, CoxA16 at home and abroad with the control virus strains, phylogenetic analysis Liaocheng features local strains.[Research Methods]1. Description of the study:According to the Centers for Disease Control and Prevention in Liaocheng City in 2012～2014 foot and mouth disease on the statistics, the use of descriptive epidemiology study, analyze the epidemiological characteristics of Liaocheng;2. Etiology:2012～2014 collection Liaocheng People’s Hospital for treatment of hand, foot and mouth disease specimens for laboratory studies, to meet the requirements of the samples extracted viral RNA, using RT-PCR method, foot and mouth disease virus for Liaocheng were typed identification.3. Molecular Biology Research:For foot and mouth disease laboratory specimens Liaocheng, Shandong Province by the Institute for Disease Prevention and Control Center for virus isolation and sequencing control domestic and EV71, CoxA16 reference strains, evolutionary tree, and local strains of the homologous genetic analysis.[Results]1.2012～2014 Liaocheng HFMD incidence at a high level, Liaocheng City in 2012～2014 foot and mouth disease were reported 5769 cases,4419 cases,6253 cases, with no deaths reported.2.2012～2014 patient-years Liaocheng HFMD speed increase since March, April-May in the outbreak period, significant downward trend in June, after a slow decline in the incidence of August, in the plateau, in January, February, November, December onset at a low level.3.2012～2014 Liaocheng eight counties, economic development zones, high-tech development zones, tourist resorts have reported cases of hand, foot and mouth disease occurs, the highest incidence of Yanggu County, followed SHENXIAN, Fairmont House District, the incidence of other counties at a low level.In several cases of 92.66 in 2012～2014 Liaocheng children 5 years old and for the number of cases; 4 2012～2014 Liaocheng HFMD minimum age for a month, the maximum age of the patients was 46 years old%,93.05%,94.73%; 6 years and older age group, the lowest proportion of illness.5. Liaocheng major pathogens of HFMD and EV71 virus CoxA16,2012～ 2014 EV71 virus accounted for 73.21% of the total samples detected,61.83%, 67.02%, CoxA16 detect viruses accounted for 24.49% of the total sample,33.75 percent,30.46%, other enterovirus infections proportion between 2.30%-4.42%.6.2012～2014 years EV71 Liaocheng local strains and subtypes C4a in the same branch, with each subtype strains and the C4a average genetic distance from the nearest subtype, indicating that the local strain of EV71 EV71 C4a Liaocheng subtype, EV71 strains and other places Liaocheng domestic and regional epidemic strain EV71 consistent.7.2014 5 CoxA16 Liaocheng whole place belongs to B1 subtype strains, B1 subtype is divided into two clusters, which belong B1a, B2b two evolutionary branches of the phylogenetic tree shows CoxA16 Liaocheng local strains and other parts of the country CoxA16 popular consistent strain.[Conclusion]1.2012～2014 HFMD patients who Liaocheng, Liaocheng distributed in 8 counties, the high season for 4-5 months, the annual HFMD cases have occurred.2. Liaocheng foot and mouth disease in children aged 1-3 based, prone to respiratory failure and other fatal symptoms,,male high incidence in women, in rural areas of high incidence in the city.3. Liaocheng major pathogens of HFMD and EV71 CoxA16 virus, which was the dominant strain EV71, EV71 patients with severe complications caused by infection.4.2012～2014 EV71 EV71 C4a Liaocheng local strains subtype, consistent with other domestic and regional EV71 epidemic strain.5.2014 CoxA16 Liaocheng local strains belonged to subtype B1a subtype evolutionary branches, CoxA16 Liaocheng local strains and other parts of the country are consistent CoxA16 epidemic strain.[Experiences and Recommendations]1. Liaocheng government and society need to work together to strengthen the environment clean and remediation work, especially multiple counties need to take active control measures.2. To strengthen the medical laboratory construction, the introduction of high-level personnel and high-tech detection equipment to enhance clinicians HFMD prevention training to improve the diagnosis and treatment of foot and mouth capability.3. Strengthening social health education, promote hygiene habits, the formation of disease prevention, the foot and mouth disease prevention and control at the source.