| BackgroundCardiac neurosis as a function of neurosis is special, its main clinical manifestations are associated with cardiovascular disease symptoms, such as chest pain, chest tightness, heart palpitations. Cardiac neurosis symptoms in young and middle-aged women, the incidence of menopausal women accounted for the first, and in patients with cardiovascular disease in patients with cardiac neurosis is not less than 10%, not a lack of elderly patients. Office workers, teachers, doctors,engaged in the mental labor incidence than manual group. In recent years, with the increasingly fierce competition, the accelerated pace of life and work, mental stress, the incidence rate of cardiac neurosis is increasing, causing people to the attention and exploration of disease. According to statistics, no physical disease incidence of mental disorders accounted for more than 30% of patients in the Department of Cardiology, the majority of cardiac neurosis. There are reports that the prevalence of cardiac neurosis is about 1/5-1,1/3. According to statistics, in recent years the neurosis patients have accounted for 1/5 of the total outpatient.ObjectiveThis topic through the use of related scales were assessed and given Guipi Decoction treatment and metoprolol was given before and after treatment in patients with symptoms to improve the situation, provide an objective basis and by comparing the effect of Guipi Decoction intervention for patients with cardiac neurosis. Create a set of scientific and clinical treatment, standard, convenient for the disease.MethodsFrom 2014 January to 2015 March, in the heart center of Guangdong ProvinceTraditional Chinese Medical Hospital, Department of internal medicine clinic outpatient and inpatient wards of cardiac neurosis, strictly execute the test cases of diagnostic criteria, inclusion criteria, exclusion criteria,90 patients were satisfied from selected as subjects, randomized controlled method, the patients were randomly divided into continuous treated with Guipi Decoction oral (treatment group) and continue to give Metoprolol Tartrate Tablets oral (control group), each group of 45 people. January/courses, a total of two groups were a course of treatment. Before and after the treatment in the two groups by the clinical trial found the symptoms improved, treatment and other relevant parameters, so as to get the statistical data required for this test, the measurement data using t test, count data using chi square test and 2, in addition to the clinical trials were analyzed by SPSS18.0 software, in order to to analyze and study the clinical therapeutic effect of Guipi Decoction on the treatment of in use in cardiac neurosis.Resultsthe following clinical curative effect:the treatment group and the control group in the total efficiency were 96% and 91%, by rank sum test shows that z=-2.133, P=0.033<0.05, two groups was statistically significant the difference in efficacy, but the treatment group effective rate is higher than the control group, which indicates that with the control group comparison, better clinical therapeutic effect in the treatment group, two groups of specific index comparison:before treatment, the treatment group and the control group:the scores of total score, heart palpitations, shortness of breath, chest tightness, dizziness, insomnia, heavy in the head and body, hands trembling, sweating, chest pain, fatigue and anorexia P values were0.317,0.676,0.677,0.834,0.831,0.674,0.677,0.540,0.517,0.532,0.698 and 0.669, these 12 values are>0.05, we can draw a comparison between the integral statistical significance before treatment of the treatment group and the control group in this experiment the does not exist. After treatment, the treatment group and the control group:the scores of total score, heart palpitations, shortness of breath, chest pain, chest tightness, dizziness, head and body trapped heavy, hands trembling, sweating, fatigue, insomnia and anorexia P values were 0,0.021,0.029,0.017,0.021,0.015,0.038,0.002, 0.027,0.014 and 0.003,0.031,<0.05, the value can be two groups after the treatment of the integral comparison had statistical significance. The treatment group symptom score and total score of the control group before and after treatment, heart palpitations, shortness of breath, chest pain, chest tightness, dizziness, head and body trapped heavy, hands trembling, sweating, fatigue, insomnia and anorexia were compared, the P values were 0,0.023,0.041,0.022,0.016,0.027,0.015,0.033,0.030,0.022,0.019 and 0.001, all<0.05, the symptoms of the two groups was statistically significant difference in the scores before and after treatment. Comparison of the treatment group and the control group before and after treatment in the integration group, P values were 0<0.05, two were visible in their differences before and after treatment was statistically significant, comparison of recurrence after treatment:the treatment group and the control group 4 weeks after treatment the recurrence rate were 4.4% and 6.7%, and the 2 test was obtained between P=0.616>0.05, 4 weeks after treatment between the two groups of the recurrence was not statistically significant, the safety observation:under the guidance of experts, in the course of clinical treatment in this experiment involved in strictly follow the normative use of drugs, not drugs in clinical treatment of patients with the results of the tests for the application of lead to difficulty in breathing, confusion, don’t sleep safety and side effects such as cardiac arrhythmia.ConelusionThrough the test, can be obtained by addition and subtraction of Guipi Decoction is better than that of using oral Metoprolol Tartrate Tablets oral in the treatment of blood deficiency type of cardiac neurosis heart palpitations,shortness of breath, chest tightness, chest pain, fatigue, insomnia and other symptoms, and the total efficacy than the use of metoprolol tablets in treatment of stone sour wine, provide an objective basis for the spleen Decoction on clinical efficacy in patients with cardiac neurosis, but also in terms of the characteristics of traditional Chinese medicine treatment of cardiac neurosis is rich And innovation. |
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