| GERD (gastro-esophageal reflux disease, GERD) refers to the stomach and duodenum contents to reflux in the esophagus, causing a series of specific changes to the esophagus, usually Clinical manifestations:Regurgitation, acid reflux, heartburn, chest pain. According to March 2013, the new GERD diagnosis and treatment guidelines from the American College of Gastroenterology (ACG) published (Am J Gastroenterol,2013,108 (3):308-328) will divided it into erosive gastroesophageal reflux disease (reflux esophagitis) and non-erosive. At present the pathogenesis of GERD mainly in molecular, gene expression, and Helicobacter pylori aspect, in addition, the autonomic nervous also has a new study in In terms of impact of GERD. But fundamentally because the esophagus own defense weakened and acidic attacks on enhancing the role of the esophagus, So that loss of coordination between the interaction. By recent clinical studies in the treatment of gastroesophageal reflux disease found the patients suffer from gastroesophageal reflux disease who have varying degrees of autonomic dysfunction, However the cause causing by autonomic nerve disorder is the poor long-term life posture caused by compression of the spinal facet joint disorders, autonomic nervous system, which is often reflected in the autonomic sympathetic and parasympathetic aspects of dysfunction. When the sympathetic nerve dysfunction or by suppression, gastrointestinal function will be disorder, clinical manifestations of sympathetic inhibition, parasympathetic nervous excitement, speed up the stomach and intestines, gastric acid secretion, gastroesophageal reflux symptoms. While sympathetic to the stomach from the chest section of spinal cord 6-10, through splanchnic nerve to the celiac ganglion, postganglionic fibers has been issued by the celiac plexus ganglion cells distributed in the stomach with the vessel branches (vessel wall, smooth muscle, glands). In this study, the spinal therapy is mainly to solve the problem of the autonomic nervous system disorders in gastroesophageal reflux disease and how to evaluate its therapeutic effect in this method alone. Therefore, in the treatment of gastroesophageal reflux disease, to be dealt with conditioning the autonomic nervous system, can achieve more satisfactory therapeutic effect.Objective:To discuss the relativity between spinal therapy with proton pump inhibitors and gastroesophageal reflux disease, and therapeutic of spinal therapy on gastroesophageal reflux disease.Methods:To analysis 120 cases reflux esophagitis (RE) patiens in our hospital date from May 2013 to June 2014, diagnosised by Degestitv Endoscopy. randomly divided the pat ions into three groups. Group A (spinal therapy group) 40 cases (16 males,24 females), given treatment by spinal therapy and placebo; Group B (control group) 40 cases (18 males,22 females), given lansoprazole treatment; group C (treatment group),40 patients (25 males,15 females) given treatment by spinal therapy with proton pump inhibitor (PPI) therapy. Three groups treatment eight weeks at the same time, after the end of treatment, by gastroesophageal reflux disease questionnaire (RDQ) and endoscopic assessment of its efficacy.Results:After treatment, the three groups of patients symptom score and endoscopic grading decreased in varying degrees, the differences were statistically significant (P<005.). The cure rate was 40% for treatment group in the overall effect, markedly effective rate was 87.5%, the total efficiency was 95%, significantly higher than the other two groups, the differences were statistically significant (P<0.05). In endoscopy, the cure rate was 25% in the treatment group, markedly effective rate was 62.5%, total efficiency was 75%. Cure rate of three groups, markedly effective rate and endoscopy grade improvement was statistically significant difference (P<0.05), comparable. No serious adverse events during the three groups of patients treated.Conclusion:Spinal therapy have a certain treatment effect on reflux esophagitis; Spinal therapy with PPI can be a safe and effective to cure reflux esophagitis, which is better than the other two groups. |
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