Systemic Sclerosis Associated Interstitial Lung Disease Clinical Symptoms Analysis And Follow-up Observation

Objective Explore scleroderma associated pulmonary interstitial lesions of laboratory data, HRCT of the lung and lung function.Methods Scleroderma associated with pulmonary interstitial lesions were retrospectively analyzed the clinical features, radiological features and treatment of follow-up. Choose hospitals in anhui province in January 2013 rheumatism lead during October 2013 inpatient and outpatient diagnosis of SSc(including patients with ILD) a total of 45 cases, 3 cases of male, female 42 cases. Minimum age 22 years old, the biggest 66 years old, mean age 39.8 ±11.39 years old. All SSc patients were accord with the rheumatology 1980 SSc classification standards promulgated by the consultation of; All patients were conducted lung HRCT and pulmonary function tests. Accompanied by pulmonary interstitial lesions of SSc- 35 patients with ILD, this group of patients with interstitial lung disease(ILD) in the diagnosis of main basis of chest radiographic inspection results: lung high-resolution CT(HRCT of the lung) performance for the consolidation of the ground glass shadow, shadow, grid, or a funicular, honeycomb structure, such as nodular shadows performance or chest X-ray net-like, nodular or honeycombing diagnosis of ILD. Cases confirmed by two has the doctor of doctor of vice director of the above title confirmed at the same time. Rule out other autoimmune disease, infection, tumor. In 35 patients with SSc- ILD treated were followed up for 6 months or more, 35 patients with SSc- ILD used small dose of corticosteroids and penicillamine treatment, including the use of 18 patients with cyclophosphamide(observation group), CTX doses of intravenous drip, 0.6 1 times every 2 weeks or 0.5 1.0 / m2, 1 times every four weeks; Unused 17 patients with immune inhibitors(control group)Results In 45 patients with SSc, the SSc- ILD, 35 patients and 77.8% of this group of patients with SSc. SSc- median duration of 48 patients with ILD(25), the median duration of patients with pulmonary interstitial lesions 24(21.25, 21.25), the difference statistically significant(P = 0.027); SSc- ILD in patients with arthritis(P = 0.022), and muscle pain(P = 0.042), the proportion of chest short breath(P = 0.003) higher than that of without pulmonary interstitial disease group; Laboratory tests of SSc- ILD group of ESR(P = 0.003) than without pulmonary interstitial lesions SSc group; Ig G is lower than the SSc group(P = 0.044). Lung function SSc- ILD group compared with SSc group, FVC(P = 0.001), FEV1(P = 0.003), PEF(P = 0.008), VC(P = 0.003), the FRC(P = 0.000), the RV(P = 0.001), TLC(P = 0.001), DLCO(P = 0.000), the difference was statistically significant. In the different period of HRCT of the lung, FVC, FEV1, PEF, VC, RV, TLC, DLCO P values, less than 0.05, the difference was statistically significant. CTX treatment group than the control group(observation group) its FVC, FEV1 / FVC, VC, DLCO improved obviously, the difference was statistically significant(P < 0.05).Conclusions SSc- ILD is a common complication of SSc; In patients with SSc- ILD, the features of HRCT of the lung and lung function has a certain relevance, lung function for the diagnosis of pulmonary interstitial disease have a certain value; Compared with patients with pulmonary interstitial lesions in the somatosensory cortex(SSc), SSc- ILD patient’s clinical symptoms and lung lesions, treatment is difficult. SSc- ILD CTX treatment in improving the imaging and lung function have certain curative effect.