A Study Of BDNF And CRH In Patients With Post Ischemic Stroke Depression

Objective This study was aiming to explore the incidence of PSD, and the significance of dynamic change between brain derived neurophic factor(BDNF) and corticotropin releasing hormone(CRH) in post-stroke depression.Methods We collected 55 cases of stroke patients and 25 cases of healthy check-up croud, the stroke patients were divided into PSD group(n=25) and non-PSD group(n=30). The BDNF and CRH levels in all group were detected on several time points. We used NIHSS for measuring the nervous functional defects, BI for activity of daily life, m RS for independent living ability. The levels of serum BDNF and CRH from the control group was measured just one time.Results 25 patients were diagnosised with PSD from the 55 cases, the incidence of PSD was 45.5%. There were no significant differences between the two groups in the aspect of baselines, for example, age, gender, education level, smoking, drinking, BMI, lesion, atrial fibrillation, homocysteine, low density lipoprotein cholesterol. Comparison between groups, Serum BDNF was significantly higher in non-PSD patients than PSD group at all time points, serum CRH was significantly also lower in non-PSD patients than PSD group. Correlation analysis showed that BDNF and CRH are negatively correlated in PSD patients before treatment.Conclusion we should attaches great importance to PSD because of the high incidence in clinic. BDNF and CRH was involved in the development of PSD, both has the interaction relations, dynamic detection of serum BDNF and CRH concentration can predict PSD and guide its treatment.