Effect Of Dexmedetomidine In Suppressing Cardiovascular And Hormonal Responses To General Anaesthesia For Caesarean Delivery

objective: To investigate the effect of dexmedetomidine in suppressing cardiovascular and hormonal responses to general anaesthesia for caesarean delivery. Methods : After ethical approval, 40 parturients scheduled for elective caesarean delivery under general anaesthesia were randomly allocated to receive either placebo, or 0.8μg/kg/h intravenous dexmedetomidine(n = 20 per group) 20 min before induction. Anaesthesia was induced using a rapid-sequence technique, and was maintained with propofol target-controlled intravenous. Changes in maternal heart rate, mean blood pressure, uterine tone, serum cortisol level, and Apgar scores and acid–base status were recorded. Results: During the operation, patients receiving dexmedetomidine had smaller increases in heart rate, lower mean blood pressures, lower serum cortisol levels and better uterine tone(P < 0.01) than those in the placebo group. Apgar scores and acid–base status were similar in the two groups. Conclusion: Preoperative administration of dexmedetomidine 0.8 μg/kg/h is effective in attenuating the maternal haemodynamic and hormonal responses to caesarean delivery under sevoflurane anaesthesia without adverse neonatal effectsobjective: To investigate the dose-effect of dexmedetomidine in suppressing cardiovascular and hormonal responses to general anaesthesia for caesarean delivery. Methods : After ethical approval, 60 parturients scheduled for elective caesarean delivery under general anaesthesia were randomly allocated to receive either 0.4μg/kg/h, or 0.6μg/kg/h,0.8μg/kg/h intravenous dexmedetomidine(n = 20 per group) 20 min before induction. Anaesthesia was induced using a rapid-sequence technique, and was maintained with propofol target-controlled intravenous. Changes in maternal heart rate, mean blood pressure, uterine tone, serum cortisol level, and Apgar scores and acid–base status were recorded. Results: During the operation, patients who received infusion of 0.6μg/kg/h,0.8μg/kg/h of dexmedetomidine had smaller increases in heart rate,lower mean blood pressures,lower serum cortisol levels and better uterine tone(P < 0.01) than those in the 0.4ug/kg/h group. Apgar scores and acid–base status were similar in the two groups. Conclusion: Preoperative administration of dexmedetomidine 0.6μg/kg/h,0.8 μg/kg/h is effective in attenuating the maternal haemodynamic and hormonal responses to caesarean delivery under sevoflurane anaesthesia without adverse neonatal effects.