Circulating Tumor Cells Of The Clinical Value And Analysis In Non-Small Cell Lung Cancer

Objective:Lung cancer is also called bronchial lung cancer, is originated in the bronchial mucosa malignant tumor. Recurrence and distant metastasis is the main cause of death in patients with lung cancer. One of the key steps of the tumor’s Distant metastasis is tumor cells falls in peripheral blood circulation. The tumor cells by the circulation of the blood to other organs and tissues, and form metastatic lesions. By monitoring circulating tumor cells in the peripheral blood circulation, that can predict early postoperative patients with tumor progression risk, and then found that lung cancer micrometastases and early treatment is to improve the survival rate of the key factors. So, By monitoring circulating tumor cells (CTCs)in the peripheral blood circulation, provides important evidence for the selection of treatment for postoperative patients with lung cancer. The research of the relationship between TNM staging of non-small cell lung cancer and the detection rate of different types of circulating tumor cells in peripheral blood, evaluation of non-small cell lung cancer patients after surgery early micrometastases change, for lung cancer patients after surgery provides important evidence for the selection of treatment.Methods:Fifty-seven patients with non-small cell lung cancer (NSCIC) be in our hospital received detection of circulating tumor cells in September 2014-March 2014, for comparative analysis between tumor size(T staging), lymph node metastasis (N staging), distant metastases (N staging), TNM’s staging of each tumor patients and the detection rate of different types of circulating tumor cells, and analysis relevant comparisons between the patient’s gender, age, histological type, Body Mass Index with the detection rate of circulating tumor cells.Results:1. The detection rate of interstitial CTCs and the tumor size (T), distant metastases (M), TNM staging present correlation (P< 0.05). The T. N. M stage increased, the positive rates of interstitial CTCs increased(The positive rates of interstitial CTCs of T1. T2. T3. T4, and the stages were 7.6%,40.0%, 40.0%,66.6%; The positive rates of interstitial CTCs of NO. N1、N2、N3, and the stages were28.1%,36.3%,55.5%,60.0%; The positive rates of interstitial CTCs of M0. M1, and the stages were32.0%.71.4%). The TNM staging is too later, the detection rate of interstitial type CTCs is too higher (The positive rates of interstitial CTCs of Ⅰ、Ⅱ、Ⅲ、Ⅳ, and the stages were20.0%.26.6%. 53.3%、71.4%).2. The detection rate of epithelial type, mixed type CTCs and the tumor size (T). lymph node metastasis (N)、distant metastases (M)、TNM staging no significant correlation (P>0.05).3、The gender、age、histological type and Body Mass Index as the influencing factors of CTCs detection rate. Results show that it’s no obvious correlation between the detection rates of the interstitial type、epithelial type、mixed type CTCs with the gender、age、 histological type and Body Mass Index of non-small cell lung cancer patient (P>0.05, no statistical significance).Conclusion:1. The interstitial type circulating tumor cells is closely related to the TNM staging of non-small cell lung cancer, circulating tumor cells (the interstitial CTCs) may be have important significance in micrometastases monitoring of the patients with non-small cell lung cancer.2. Detection of circulating tumor cells compared to the traditional tumor monitoring method maybe can early warning recurrence of the tumor metastasis.3. Circulating tumor cells (the interstitial CTCs) and the patients’ gender、age、histological type and Body Mass Index has no obvious correlation.