Analysis Of Subjective Well-being And Its Influencing Factors In Patients With Ankylosing Spondylitis

Objective This study is according to the clinical features of Ankylosing Spondylitis, to understand the general living conditions of the various factors of subjective well-being of Ankylosing Spondylitis, on the basis of routine clinical treatment, Our study tried to understand the status of subjective well-being of patients with ankylosing spondylitis, explored the possible influencing factors in AS patients by determination of the subjective well-being in patients with AS. To guide the clinical treatment and improve the quality of life of patients to provide a better basis.Methods 200 patients including 165 men and 35 women with ankylosing spondylitis were collected from Department of Rheumatism and Immunity, the First Affiliated Hospital of Anhui Medical University through cluster sampling methods. Epidemiological datas of all AS patients were collected, including general characteristics such as sex, age, marital status, occupation, duration et al, Spinal pain was measured by visual analogue scale(VAS), disease activity by Bath Ankylosing Spondylitis Disease Activity Index(BASDAI), functional capacity by Bath Ankylosing Spondylitis Functional Index(BASFI), and family care degree by Family APGAR Index. Subjective well-being was assessed in patients by General well-being(GWB). Meantime, ESR and CRP were determinedResults1. The t-test was used to compare the parametric variables for detecting differences between groups. The results showed that the SH, O, Total score and VAS, BASFI, and BASDAI scores all had statistical differences between different occupations and different duration.2. The results of t-test showed that scores of all dimensions had significant differences among the two groups on S, SH. The composite score among the groups showed that the general well-being of physical was worse than that of the mental.3. The results of t-test showed that S, SH scores higher in city than Village, there are significant difference(P<0.05); the rest dimension of the general well-being and total score in both groups no significant difference between(P>0.05).4. AS patients were divided into three groups including Better group, General group, poor group based on sleep quality of AS. There were statistically significant difference of scores of E, SH,O, RT. among these three groups. Pairwise comparisons of dimensions with significant difference among the three groups showed that there were statistically significant difference between Better group and general group, Better group and poor group, General group and poor group. The composite score indicated that the worse sleep quality of AS patients, the worse general well-being.5. AS patients were divided into three groups including particularly satisfied group, Satisfied group, Not satisfied group based on life satisfaction of AS. There were statistically significant difference of scores of E, S, SH, O, RT among these three groups. Pairwise comparisons of dimensions with significant difference among the three groups showed that there were statistically significant difference between particularly satisfied group and satisfied group, satisfied group and not satisfied group, particularly satisfied group and not satisfied group. The composite score indicated that the better life satisfaction of AS patients, the better general well-being.6.AS patients were divided into four groups including very optimistic group, optimistic group, general group, feeling bad group and No hope group based on their attitudes toward the prospects for the treatment of this disease. There were statistically significant difference of scores of E, S, SH, O, RT. among these five groups. Pairwise comparisons of dimensions with significant difference among the five groups showed that there were statistically significant difference between very optimistic group andgeneral group, very optimistic group and feeling bad group, optimistic group and general group, and optimistic group and feeling bad group,general group and no hope group. The composite score indicated that the worse the mentality of AS patients toward the disease, the worse general well-being.7.compared with the family functioning AS groups(APGAR>6),except Hand O, the rest scores of family dysfunction AS groups(APGAR≤6) were statistically significant differences(P<0.05). General well-being of patients with family dysfunction ankylosing spondylitis group was significantly lower than family functioning(P <0.05).8. compared with the stability AS groups(BASDAI<4),except H, the rest scores of active AS groups(BASDAI≥4) were statistically significant differences(P<0.05). General well-being of patients with active ankylosing spondylitis group was significantly lower than stability(P<0.05).9.compared to AS patients whose functional status is poor(BASFI ≥ 5), except SH,the rests of SF-36 scores were higher in AS patients whose functional status(BASFI<5) is good, and the difference was statistically significant(P<0.05). General well-being of patients with better functional status ankylosing spondylitis group was significantly higher than poor(P <0.05).10.Univariable and Multivariable regression analysis finally found the following variables to be statistical significance with General well-being: Sleep quality, Life Satisfaction, Therapy prospects, APGAR, BASDAI.Conclusion Sleep quality, Life Satisfaction, Therapy prospects, APGAR, BASDAI can affect the general well-being. Recognizing the complex relationship between these factors with subjective well-being of ankylosing spondylitis,can help us to further develop management strategies,to improve ankylosing spondylitis well-being.