Study On The Correlation Between Mri Features And The Biological Characteristics Of Brain Tumor And Surrounding Tissue

Objective:To study the MRI imaging characteristics of brain tumor and its surrounding tissues and its biological characteristics, judgment of glioma grading,improve the preoperative diagnosis and differential diagnosis of the tumor.Methods:To collect 693 cases of brain tumor of The Second Hospital of Hebei Medical University in February 2013-September 2014, which were confirmed by pathology, including 99 cases of low grade gliomas(grade I-II), 150 cases of high grade glioma(grade III-IV),(among which 78 cases of grade III glioma,72 cases of grade IV glioma),120 cases with brain metastases tumor,(including 42 cases of single metastases), a total of 77 cases of primary intracranial lymphoma, which were pathologically diagonosised as diffuse large B cell lymphoma, 146 cases of meningioma(level I), 101 cases of other brain tumors, such as vascular net woven tumor and craniopharyngioma etc,and to employ brain conventional MRI scanning such as in all cases before operation.Read and analysis the T1 WI, T2 WI and T1 enhancement scanning image of the collected 693 cases of brain tumor, find out the existence of brain edema tumors and peritumoral brain edema > 0.5 cm in diameter, and three regions were manually drawn by the signal differences in T1 WI enhancement scanning sequence of tumor and its surrounding tissues, sketching the most obvious strengthening area of tumor as A zone, the peritumoral area with signal differences between the tumor and the peritumoral brainedema area without strengthening, namely "active" area as B area, the peritumoral brain edema area without strengthening as C area. The volume of each area was get by measuring the area of the regions of interest(ROI) with the post-processing software. The spss18.0 statistics software was used for the statistical analysis. The t test and the ANOVE was used to compare statistical index(the ratio of area B and C) in the grade III and IV glioma, the single metastases and circular reinforcedlymphoma, the linear regression analysis was used to analysis the correlations of volume of area B and A and C between the grade III and IV glioma, the single metastases and circular reinforced lymphoma.Results:1 No area B can be drawn in the collect of a total of 693 cases of brain tumor, including 146 meningioma cases and 99 grade I, II glioma cases, in which no edema exists or edema area less than 0.5 cm indiameter, so there is no active area in the edema. Active area can be drawn in 51 cases of grade Ⅲ glioma, accounting for about 65.4% of the collect 78 cases of grade III glioma. The number is 60 cases for grade IV glioma, accounting for about 83.3% of the collect 72 cases of grade IV glioma. Active area can be manually outlined in 28 cases, which accounted for about 66.7% of the 42 single metastases in the collect of a total of 120 cases of metastatic tumor; No active area can be drawn in 45 cases with nodular enhancement of a total of 77 lymphoma, the number is 20 cases for 32 cases with annular enhancement of the collect 77 lymphoma cases, of which pathological types were diffuse large B cell lymphoma, accounting for about 62.5% of the 32 lymphoma cases with annular enhancement; There were no peritumoral edema in the rest 101 cases of brain tumor.2 The independent samples t test was used to compare the differences between high grade glioma tumor volume and low grade glioma tumor volume, high grade glioma tumors volume was(59.0262±7.5248) cm3, and low grade glioma tumors volume was(41.2539±15.8140) cm3, P < 0.05, with statistical significance, the results showed that high grade glioma tumor volume were significantly different from low grade glioma. The t test also was used to compare the differences of the edema volume(area B and C), high grade glioma edema volume(area B andC) was(59.0262±7.5248) cm3, and low grade glioma edema volume(area C) was(35.5869±21.3786) cm3, P < 0.05, with statistical significance, the results showed that high grade glioma edema volume were significantly different from low grade glioma.3 The independent samples t test was used to compare the differences between Grade III glioma activity area volume and edema area volume ratio(B/C)and grade IV glioma activity area volume and edema area volume ratio(B/C), the grade III glioma B/C ratio was 0.11230±0.02169, and the grade IV glioma B/C ratio was 0.22434±0.03458, P < 0.05, with statistical significance, the results showed that the grade III glioma activity area and edema area ratio(B/C) was statistically different from the grade IV glioma activity area and edema area ratio(B/C).4 The independent samples t test was used to IV glioma activity area volume and edema area volume ratio and single metastases activity area volume and edema area volume ratio(B/C), the grade IV glioma B/C ratio was 0.22434±0.03458, and single metastases B/C ratio was 0.14979±0.01580, P < 0.05, with statistical significance.5 The independent samples t test was used to IV glioma activity area volume and edema area volume ratio and lymphoma active area volume and edema area volume ratio(B/C), the grade IV glioma B/C ratiowas 0.22434±0.03458, and lymphoma with annular enhancement B/C ratio was 0.19360±0.01653, P < 0.05, with statistically significance.6 The independent samples t test was used to compare the differences between single metastases activity area volume and edema area volume ratio(B/C) and lymphoma with annular enhancement activity area volume and edema area volume ratio(B/C), the single metastases B/C ratio was 0.14979±0.01580, the lymphoma with annular enhancement B/C ratio was 0.19360±0.01653, P < 0.05, with statistically significance.7 Linear correlation analysis was used to test the respectively correlations between the tumors(area A) volume and edema area(area C) volume and its active area(area B) volume of grade III and IV glioma, single metastases and lymphoma with annular enhancement, the results showed that r = 0.932, P < 0.05, with statistical significance. The correlation coefficient Linear correlation analysis was used to test the correlations between edema area(area C) volume and activity area(area B) volume, results showed that r = 0.524, P < 0.05, with statistical significance.Conclusion:1 For grade III and IV glioma, lymphoma with annular enhancement and single metastatic tumor, the grade IV glioma active area acounted for a highest percentage, followed by single metastatic tumor, grade III glioma and lymphoma with annular enhancement.2 Grade IV glioma activity area accouted for a highest ratio to its edema area, then followed by lymphoma with annular enhancement, single metastatic tumor and grade III glioma.3 For grade III and IV glioma, annular enhanced lymphoma and single metastatic tumors, the greater the volume of the tumor and edema was, the wider the scope of the active area would be.4 Important diagnosis and differential diagnosis clues could be obtained and significant information for clinical surgery and chemotherapy could be provided through the manual sketch of activity area.