Study Of The Effect Of The Blood Coagulation In Primary Lung Cancer Patients Treated With Huisheng Oral Solution During Perioperative Period

Objective: To explore the effect of the blood coagulation in primary lung cancer patients treated with Huisheng oral solution during perioperative period.Methods: The clinical data of primary lung cancer patients treated with operation from thoracic surgery departments of 4th Hospital of Hebei Medical University,2nd Hospital of Hebei Medical University,Handan Centre Hospital, Cangzhou Centre Hospital as well Subsidiary Hospital of North China Coal Medical University during March 2013 to March 2015 were analyzed.There were 27 patients from 4th Hospital of Hebei Medical University,21 patients from 2nd Hospital of Hebei Medical University,22 patients from Handan Centre Hospital,19 patients from Cangzhou Centre Hospital as well 15 patients from Subsidiary Hospital of North China Coal Medical University,in which 60 patients in the trail group and 44 patients in the control one.All the patients were diagnosised through pathological evidence.Data included patients’ gender,age,height,weight,stage of lung cancer,evaluation of ECOG, whether there were basical diseases and complications, edema of lower extremity,varicosity,congestive heart-failure,family history of thromboemboli- sm disease or not,and operation methods.Criteria of patients in the two groups including diagnosis meeted the standard of primary lung cancer,patients fited to operation indication,aged from 18 to 75 years old,no limitation to gender, ECOG should be 0~2,lifetime should be longer than 3 months as predicted,no allergic history to the component of Huisheng oral solution,no medical history of DVT,PE,stroke,AMI,no acute spinal cord injury,joint replacement,or multiple trauma of hip joint,pelvis and fracture of lower limb within a month. Exclusion criteria of patients in the two groups,patients without operational opportunities,aged younger than 18 years old or older than 75 years old, patients with serious allergic history,or medical history of DVT,PE,stroke or AMI,or acute spinal cord injury,joint replacement,and multiple trauma of hip joint,pelvis and fracture of lower limb within a month,patients with psychosis that were not controlled well,not following the instruction from doctors, having CNS disease,or with obviously high intracranial pressure,or psychoneurosis,taking part in other trails at the same time,should not be participated in doctors’ consideration.Patients in the trial group were subjected to operation treatment and took orally Huisheng oral solution.(20ml,2/day, before operation;20ml,3/day,after operation)Patients in the control group were only subjected to operation treatment.All the patients were not accepted any other anticoagulant treatment within 28 days after operation.Blood routine test, prothrombin time,activated partial thromboplastin time,thrombin time, fibrinogen,D-dimer,antithrombin-III and protein C were detected before operation/treatment with Huisheng oral solution,24 hours after operation,72 hours after operation,10 days after operation,28 days after operation.Plasma Protien C were centrifuged,freezingly collected,detected by Assayllax Human Protein C ELISA Kit regularly.All the data were analyzed by SPSS 13.0. Measurement data were described by mean±standard deciation,while enumeration data were described by percentage.The measurement data were used by t-test if meeted normal distribution and homageneity of variance,otherwise they were used by non-parametric test.Meanwhile,the enumeration data were used by X2-test.Because this study was designed to repeated measure,the results were analyzed by rariance analyzed.Results: There was no difference in patients from every centre, gender,age,stage of lung cancer between two groups,indicated that the distribution of them were balanced. From the data of every index before operation except for d-dimer,there was no significant difference between the trail group and the control group.PLT peaked at 10 days(about a week) after operation,which higher than before operation,there was significant difference between them in the trail group.(P<0.001) PLT peaked at 10 days(about a week) after operation,which higher than before operation,there was significant difference between them in the trail group.(P=0.001) PLT peaked at 10 days(about a week) after operation,there was significant difference compared to he trail group and the control one.(P=0.043) PLT became normal in a month after operation,and there was significant difference between the trail group and the control one.(P=0.044) For d-dimer,there was different from the beginning of 24 hours after operation(P=0.043),raising at 24 hours and decreasing in a month after operation.For the distribution of d-dimer from 24 hours to 10 days(about a week) after operation between two groups, there was significant difference.Conclusion: The highest risk of coagulation of patients with lung cancer treated with operation is about 10 days(about a week) after operation.The was difference in PLT and d-dmier between the trail group and the control group. There are advice that doctors should carry out anticoagulants treatment as soon as possible after operation of lung cancer.Huisheng oral solution can be an option for the anticoagulants treatment after operation of lung cancer.