| This study is conducted to investigate the clinical pathologic features and treatments of borderline ovarian epithelial tumors,and analysis the factors significantly influence their prognosis.By retrospective investigating, following aspects of the clinical data from 90 patients recieved operation for borderline ovarian epithelial tumors in Drum Tower Hospital during the last 14 years are collected:(1) the main clinical pathologic features;(2) the tumors and frozen section pathological results in the operation; (3) treatments, the final pathology results; (4) the post-operation therapy (second surgery, chemotherapy after surgery and so on), (5) recurrence and metastasis.Among these 90 cases,87 patients were interviewed and 3 were out of reach. Our follow-up times was 6 months to 14.5 years and the average follow-up time was 4.62 ± 3.58 years.There are 3 deaths, one case died of traffic accident, two cases were stage Ⅲ patients died in the first four and eight years. According to the calculated life tables, the 5-year and 10-year survival rate of patients in this group was 97.14% and 85.71%.12 people relapse during our follow-up time, and the recurrence time was 10 months to 7.92 years. The average recurrence time was 3.44 years. In our group,the age of was 18-84 years and the mean age was 42.32 ± 17.09 years old. 50 patients were younger than 40 years old(55.56%,50/90).48 cases of 90 patients with BOT (53.33%,48/90) had no significant complaints. According to 2000-FIGO stage, there were 82 cases (91.99%,82/90) in stage I including 57 cases in stage I a (63.33%,57/90),8 cases in stage I b (8.89%,8/90),17 cases in stage I c (18.89%,17/90),and 3 cases in stage Ⅱ (3.33%,3/90),5 cases in stage Ⅲ.There were 75 cases (83.33%,75/90) of S-BOT and M-BOT,including 39 cases of S-BOT (43.33%,39/90) and 36 cases of M-BOT (40%,36/90).There were seven cases of borderline mixed tumors (7.78%,7/90) and 8 cases of rare pathological type borderline ovarian tumors (8.89%,8/90), including 5 cases of borderline ovarian endometrioid tumors, two cases of borderline Brenner’s tumor, and one case of borderline clear cell -like rumors. Borderline serous ovarian tumors had smaller age, later stage, and much more common in bilateral.But in prognosis there was no significant difference between different pathological types. Within the 90 patients,50 cases (55.56%,50/90) had fertility surgery with the average 31 years old including 43 cases younger than 40 years(86%,43/50). The patients who preserved fertility surgery significantly had younger ages (P> 0.05). There are 10 cases of fertility surgery and two cases of radical surgery relapsed, there was a significant difference (P=0.038) between the fertility surgery or radical surgery.77 cases of 90 patients (85.56%,77/90) had frozen section pathological examination, accuracy rate of which was 90.91%.13 patients(including 6 cases of phase 1,2 cases of phase Hand 3 cases of phase III) followed by adjuvant chemotherapy. But whether had postoperative adjuvant chemotherapy or not for BOT patients had no significant difference (P> 0.05)in the prognosis.The age of BOT patients were low,50.56% of patients younger than 40 years old and 33.33% of the patients had fertility requirements. BOTs were always discovered in early FIGO stage, 91.99% in I phase. BOTs had good prognosis, the 5-year and 10-year survival rate are 97.14% and 85.71%. S-BOT patients tend to have younger age, later stage, and happened more common in bilateral, but different pathological types had no significant influence in prognosis. The most important treatment of BOT was the surgery. There was a significant difference (P=0.038) between the fertility surgery and radical surgery in relapse rate. The accuracy rate of frozen section pathological examination in our group was 90.91%. It had great reference value in determining the extent of surgery. Adjuvant chemotherapy did not change the prognosis of patients with BOT. |
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