| BackgroundPeriesophagogastric devascularization is used for the treatment of portal hypertension, which blocks the collateral circulation between portal vein system and azygos venous system in order to control the esophageal and gastric variceal hemorrhage purpose caused by portal hypertension.However, the operation still has postoperative rebleeding rate.There are several reasons for rebleeding,for example,operations are not standardized, disconnection is not complete, recurrent bleeding of collateral circulation recanalization between portal vein and azygos venous,and portal hypertensive gastropathy. Aiming at how to reduce postoperative adhesions formation and new vessels and decrease rebleeding rate of esophageal variceal exists clinical significance and certain research value. ObjectiveAssess the effects of polylactic acid operative protective film in the portal hypertension rat model of periesophagogastric devascularization and discuss its application value in patients with periesophagogastric devascularization. Methods40 SD rats were randomly divided into two groups,including the experimental group and the control group. The experimental group and the control group were made prehepatic portal hypertension model by partial portal vein ligation. The rats of experimental group underwent periesophagogastric devascularization with polylactic acid operative protective film surrounding the cardia wound and the rats of control group were only operated by periesophagogastric devascularization. Rats were sacrificed after four weeks and specimens collected were made paraffin immunohistochemical staining to observe the expression of CD34 and VEGF. Observe and analyse the cardiac peripheral tissue adhesion degree and neovascularizationthe. ResultsThe control group had a wide range of adhesion in the macroscopic classification,while experimental group involved fewer adhesion and organs. The experimental group classification adhesion decreased significantly comparing with the control group and the difference was statistically significant(P<0.05). Immunohistochemistry showed that the experimental group were lower than the control group in the degree of adhesion and angiogenesis of cases, the difference was statistically significant(P < 0.05). ConclusionPolylactic acid operative protective film can prevent and reduce adhesion formation and angiogenesis in portal hypertension rats model of periesophagogastric devascularization in a certain extent. Polylactic acid operative protective film may be helpful to reduce rebleeding incidence in patients with portal hypertension after periesophagogastric devascularization. |
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