Preparation And Testing Bioadhesive Enteric Pellets And Therapeutic Effects Of STZ-induced T2DM Rats

Diabetes is a relatively common chronic diseases, can cause a variety of complications. Type II diabetes usually have overweight condition. Nowadays there is a special treatment of diabetes complicated by surgery, usually by gastric bypass surgery. These procedures have been shown to good effect, but it also has a certain degree of risk, and greater pain to the patient. This subject is hoping to develop an oral medication to achieve the purpose of surgery and reduce the suffering of patients. Raw materials intended for use in drug Carbomer 934 P and a series of materials having a cohesive effect and be enteric coated so that it can break down in the environment to form a predetermined bioadhesive film while maintaining a small dry in other environments particle state, eventually blocking food proximal small intestine with active contact, to achieve the purpose similar surgery.This paper is divided into three parts, the first is the preparation of pharmaceutical microspheres, beginning from the selection of raw materials, to the coating of the particles are coated after the completion of quality testing, to determine that it can play a role in the desired predetermined conditions. The second part is the drug microspheres formed bioadhesive film vitro testing, the paper rapid in vitro dissolution test, stability and expansion of the test, adhesion test and test glucose permeability were measured in four areas, its safety and feasibility of a visual analysis to determine their medication without adverse consequences caused death. The third part is drug tested in vivo, most want to change some of the symptoms and the secretion of hormones for diabetes research, through the study of their body weight and blood glucose determination to improve the situation of the symptoms of diabetes, glucose-dependent insulin-releasing peptide(GIP) and 1(GLP-1) study glucagon-like peptide to determine their impact on the body when you play a role, through the rational study of disease, to observe the sections of diseased tissue to determine whether the medication because animal organs drug use and to avoid being poisoned by hyperglycemia in vivo environment. The study found that the drug can replace the role of surgery to some extent, the detection phase can be identified in vitro in experimental animals which will not affect the late lethal, and some therapeutic effects which might arise. Intenal detection phase is found by treating weight loss and blood sugar in experimental animals because STZ induced diabetes are caused by excessive eased, while reducing excessive secretion of GIP, reducing its antagonistic effect on islet β cells, open its same GLP- share a stimulation pathways that GLP-1 play a role in the final restoration of islet cells for the treatment of diabetes play a role.In this study, an innovative treatment options for surgical treatment of Type II diabetes in obese patients improve, it is possible to achieve a certain effect, while reducing the pain suffered by patients in treatment. In obese type II diabetes are more high moment, the Institute brings experience may be able to treat this disease brings a new tool.