Videonystagmography Recording In Parkinson’s Disease

Background & Objective:Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterised by slowness of movement, muslcular rigidity and tremor arising from a depletion of the neurotransmitter dopamine within the basal ganglia. The basal ganglia participated in five parallel loops with the cerebral cortex. One of these cortico-basal ganglionic circuits involved with oculomotor area of the cortex. The aim of this study is to analysis ocular motor function of patients with Parkinson’s disease.Methods:① 20 patients with clinically confirmed idio-Parkinson’s disease according to UK Parkinson’s Disease Society Brain Bank Clinical Diagnostic Criteria from clinic service of PD during July 2014 till April 2015 were entered into this study,20 sex and age-matched healthy control subjects.All cases were determined by H-Y Staging,MMSE and ruled out other nervous system disease.②VNG was carried out to examine all of these patients and also 20 healthy control sudjects which including spontaneous nystagmus test (SN), gaze test(GT), saccade test (ST) (including random ocular saccade and predictive ocular saccade), smooth pursuit eye movement (SPEV) test and optokinetic nystagmus (OKN)test The data, including the latency of random saccades, the velocity of random saccades, the accuracy of random saccades, the latency of the predictive saccades, the velocity of the predictive saccades, SPEM and OKN Gain was statistically analyzed with SPSS20.0.Results:In spontaneous nystagmus (SN) test and gaze test (GT), compared with controls, increased rate of square-wave jerks (SWJ)in PD group. In the random ocular saccade pattern, increased random ocular saccades latency, decreased random ocular saccades velocity and accuracy was found in PD group. There were significant differences in velocity of several (15-30°) saccadic angles between two groups(P<0.05). In the predictive ocular saccade pattern, the latency of saccades of the PD group significantly longer than of the healthy controls(P<0.05),the velocity of which were more descended in PD group than in the healthy group(P<0.05). Gain of SPEV test was much lower in PD group than in control group(P<0.05). However, there were no significant differences in OKN test between the two groups(P>0.05).Conclusion:There is dysfunction of ocular saccade as well as SPEM in patients with Parkinson’s disease, and the cognitive function maybe be detected by predictive ocular saccade in those people. VNG test can provide the important evidence for the diagnosis for PD.