| ObjectiveThis topic using data mining and the method of retrospective study of guangdong area since 1985 physicians in the treatment of nasopharyngeal carcinoma drug prescriptions to collect and analysis, summary common TCM syndrome and the diagnosis and treatment of nasopharyngeal carcinoma in Guangdong, that inherit the guangdong area physicians for the treatment of nasopharyngeal carcinoma academic experience, for the development and application of guangdong area physicians treatment experience of nasopharyngeal carcinoma, the promotion of innovation to provide certain theoretical basis, so as to improve the quality of life of patients with nasopharyngeal carcinoma.MethodThis topic through data mining and the method of retrospective study on 1 January 1985 to December 2014, guangdong doctor of literature, including provincial domicile of origin of the physicians but mainly in the guangdong development. For all physicians for the treatment of nasopharyngeal carcinoma prescriptions are collected, after finishing all prescription data entry Microsoft Excel spreadsheet, establishing a database form Excel worksheets, and USES the SPSS 17.0 statistical software for statistical processing. The acknowledgement of guangdong in the treatment of nasopharyngeal carcinoma prescription drug analysis, discuss and summarize the common governance of syndrome of nasopharyngeal carcinoma in guangdong and the diagnosis and treatment. The use of statistical analysis methods including frequency analysis, correlation analysis and cluster analysis.Results161 collecting prescriptions in this subject first, drugs involved 184 taste. Among them, including:Chinese medicine prescription for the treatment of nasopharyngeal carcinoma are 82; Prevention and treatment of oral cavity ulcer caused by radiotherapy for nasopharyngeal carcinoma of traditional Chinese medicine prescription 58 first;Of nasopharyngeal carcinoma radiotherapy sensitization effect of traditional Chinese medicine prescription 10;Other prescriptions 11 first. Concrete results are as follows:1. This topic to collect 82 prescriptions of Chinese medicine treatment of nasopharyngeal carcinoma, the use frequency of more than 10 times of 22 in the traditional Chinese medicine, a total of 6 kinds of drug use frequency more than 30%, which the commonly used single taste traditional Chinese medicine, followed by liquorice (56.098%) (47.561%), arrowhead, fresh mushroom, mountain codonopsis (34.146%), poria cocos (34.146%), stone (31.707%), parker spreading hedyotis herb (30.488%). The above characteristics of the medicine is mostly ZhuanBing medicine, highlights the contemporary guangdong doctor targeted for the treatment of nasopharyngeal carcinoma.2. This topic the collected 82 prescriptions of TCM in 82 were divided into 18 drug class. Class is one of the most frequently used medicine tonify deficiency (31.958%), followed by the spleen medicine (12.736%), its basic compatibility medicine class as a treatment of nasopharyngeal carcinoma (NPC); And can see, tonify deficiency drug use frequency is far higher than that of other drug use frequency. And promoting blood circulation to remove blood stasis drugs (10.142%) and heat medicine (9.316%) were the main synergies compatibility medicine class, hemostatic (7.665%), and the water permeability wet medicine (4.835%), and other drug classes have some use frequency. Further study found, tonify deficiency medicine four sub-types of class is the most frequently used medicine mend angry medicine, heat medicine 5 types of class is the most frequently used medicine heat of poison.3. The second will be 161 TCM further analysis shows that guangdong doctor treatment prescriptions in nasopharyngeal carcinoma, the taste is given priority to with bitter, sweet, bitter, frequency are 33.362%,30.979% and 33.362% respectively, the cumulative frequency of 86.128%. The most frequently used for bitter medicine, the lowest frequency for mild drugs,2.723%; Medicinal properties is given priority to with warm, cold, flat, the cumulative frequency of 98.16%. Among them, use the highest frequency of sexual medicine, 38.810%,0.850% of the minimum frequency of cool sex medicine; To the frequency from high to low in turn lung, spleen, stomach, liver, kidney, heart, lung spleen and stomach of three of the cumulative frequency to reach 60.648%, more than half the total frequency. The statistical results conform to the NPC to lung spleen by 3 for targets.4.This topic collected in the first prescription of TCM prevention and treatment of oral ulcer 58, in selecting frequency more than 5 times of 30 in the traditional Chinese medicine, a total of seven kinds of drug use frequency more than 30%, which the commonly used single taste traditional Chinese medicine, followed by dwarf lilyturf (67.241%), radix rehmanniae (55.172%), radix scrophulariae (55.172%), licorice root (43.103%), honeysuckle (43.103%), spreading hedyotis herb (39.655%), radix pseudostellariae (31.034%).Above the main effect of nourishing Yin, highlights the guangdong doctor treatment of nasopharyngeal carcinoma radiotherapy of oral ulcer.5. This topic to collect 58102 in the first prescription of TCM were divided into 18 drug class. Class is one of the most frequently used medicine herbs medicine (44.615%), followed by tonify deficiency (29.808%), as a basic compatibility of medicines in the treatment of oral ulcer, and can see, the use of heat medicine frequency is much higher than other drug classes use frequency. And promoting blood circulation to remove blood stasis drugs (8.077%) were the main synergies compatibility medicine class, spleen medicine (4.038%), and the water permeability wet medicine (3.846%). Further study found, tonify deficiency medicine four sub-types of class is the most frequently used medicine fill Yin medicine, heat medicine 5 subgenera class is the most frequently used medicine in the heat of poison.6. The second will be 102 TCM further analysis shows that guangdong doctor therapy in the prevention and treatment of oral ulcer prescriptions, taste is given priority to with sweet, bitter, frequency were 40.273%,39.405%, 79.678% cumulative frequency; Medicinal properties is given priority to with cold, flat, cumulative frequency by 89.689%; Among them, use the highest frequency of cold medicine,71.401%,0.584% of the minimum frequency of hot sexual medicine. To the frequency from high to low in turn lung, stomach, heart, liver, which belong to the lung and stomach’s two by the cumulative frequency to reach 46.875%, close to half. The statistical results accord with nasopharyngeal carcinoma after radiotherapy oral ulcer role in the lung and stomach through the point of view.7.102 kinds of Chinese traditional medicine through correlation analysis, it is concluded that drug pairs trends are the following four types:(1) with a similar role in drug of wu, strengthen the treatment effect; (2) the purpose of the same drug treatment to cooperate, together promote role; (3) pathogenesis of drug used for specimen.8. Using the clustering analysis method,8.161 TCM analysis shows that after class gathered to 6 after drugs achieve stability, basic can no more points, combined with frequency analysis table and the traditional Chinese medicine clinical practice, prescription ingredients at around 10 flavour, so think poly (6 class result is more reasonable. You can see in this that guangdong physicians treat oral cavity ulcer caused by nasopharyngeal carcinoma radiotherapy core is commonly used drugs is:spreading hedyotis herb, radix glycyrrhizae, radix ophiopogonis, radix rehmanniae, radix scrophulariae, flos lonicerae, radix pseudostellariae, coastal glehnia root, poria cocos.ConelusionThis subject adopts the method of data mining and retrospective study of guangdong physicians prescription medication analysis for the treatment of nasopharyngeal carcinoma. Collect 161 prescriptions of Chinese medicine treating nasopharyngeal carcinoma, involved 184 Chinese traditional medicine. Of the acknowledgement of guangdong medicine analysis we can see in the treatment of guangdong doctor "based on lung, spleen and stomach three differentiation, pay attention to spleen benefit stomach", "mediate liver, pay attention to factors", "green pays attention to the origin, the permeability of wetting wet as the auxiliary pole", "attaches great importance to the nitrogen stasis pathogenesis characteristics of alternating knot", and "qi detoxification treatment of oral ulcer", "promoting blood circulation to remove blood stasis enhanced radiation effect" the characteristics of this will help guangdong doctor academic experience of inheritance, for the development and application of guangdong area physicians treatment experience of nasopharyngeal carcinoma, the promotion of innovation to provide certain theoretical basis, so as to improve the quality of life of patients with nasopharyngeal carcinoma. |
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