Concomitant Use Of The Inactivated Rotavirus Vaccine And Inactivated Poliovirus Vaccine

Background When a novel vaccine is put into application, the interference with other vaccines after vaccination must be taken into consideration besides the safety and efficacy. Poliomyelitis caused by poliovirus (PV) and acute gastroenteritis caused by rotavirus (RV) are both important infectious diseases in children. Definitely, both of live, attenuated oral poliomyelitis vaccine (OPV) and inactivated poliovirus vaccine (IPV) play a crucial role in preventing the severe consequences of poliovirus infection. After the introduction of live, attenuated oral poliomyelitis vaccine (OPV), China has been certified to be free of polio. However, high coverage of poliovirus vaccine is important to maintain the state of "free of polio". Rotavirus is the most common cause of severe acute gastroenteritis (AGE) in children under 5 years of age worldwide, accounting for an estimated 100 million infections,2 million hospitalizations, and 450,000 deaths each year. Oral rotavirus vaccine (ORV) has been used to prevent RV infection. OPV may have an inhibitory effect on the immune response to the first dose of ORV after simultaneously administration of ORV with OPV. There is no approved licensed inactiveted rotavirus vaccine (IRV) now. Whether coadministration of IRV with IPV will impair the immune response to any of the antigens is unknown, so research of the interaction between them is crucial for the development of IRV.Objective To evaluate the immunogenicity and interaction of coadministering inactivated rotavirus vaccine (IRV) and inactivated poliovirus vaccine (IPV).Methods 30 Wistar rats were randomized assigned to receive 3 doses of IPV at 0,4th, and 8th week with IRV either coadministered at 4th and 8th week or administered separately at 6th and 10th week, using the corresponding single vaccine as control. Serum samples were collected 4 weeks after each dose of each vaccine, and determined for neutralizing antibody teters against rotavirus and poliovirus by serum neutralization test and RV-specific IgG titers by ELISA.Results Antibody responses to both IRV and IPV antigens were not significantly different among groups(P>0.05).Conclusions Both of IRV and IPV were immunogenic when coadministration and did not interfere with each other.