Expression And Clinical Significance Of Transcription Factor FOXQ1 In Human Hepatocellular Carcinoma

bjective:To investigate the expression and clinical significance of transcription factor FOXQ1 in human hepatocellular carcinoma(HCC). Methods:FOXQ1 m RNA and protein were detected by RT-PCR and Western blot among 24 pairs of HCC tissues, paracarcinoma tissues. Immumistry was used for detection of FOXQ1 protein in 68 pairs of HCC tissues and corresponding paraneoplastic tissues.Results:The expression of FOXQ1 m RNA and protein in HCC were significantly higher than in paraneoplastic liver tissues,the expression of FOXQ1 protein was correlated with TNM stage,tumor differentiation,tumer numbers and tumer size(p<0.05). Conclusion:FOXQ1 is overexpressed in HCC.The abnormal expression of FOXQ1 is closely related to progress and clinicopahology of HCC.