The Immune Function Of Patients With Cervical Cancer Status Analysis And Its Clinical Significance

Objective:To explore the immune state of pretreatment patients with cervical cancer and its clinical significance.Methods:The peripheral blood from 90 patients with cervical cancer and 30 healthy women was sampled. CD3+, Th, Ts, Th/Ts ratio, NK cells and CD 19+ of the peripheral blood were detected by flow cytometry (FCM).Results:(1) The CD3+, NK cells and CD 19+ in the patients with cervical cancer were significantly decreased than that in healthy women and were related to their clinical outcome. To suggest the immune function were clinical outcome-dependent decreased in cervical cancer. (2) The CD3+, NK cells and CD 19+ showed no difference between the patients with normal or HPV16 cervical cancer. (3) The immune function were inhibitted in cervical squamous carcinoma than in cervical adenocarcinoma depending on small sample. (4) The CD3+ and NK cells in the patients with high risk factors of cervical cancer after surgery were decreased than non-risk factors patients. To suggest that the immune fucntion were inhibitted in high risk factors patients.Conclusion:The development and prognosis of cervical cancer are related with immune state. The immune function were inhibitted in the patients with cervical cancer and depending on clinical outcome and high postoperative risk factors, but it had no difference between the infection of HPV16. Measurement of CD3+, CD3+CD4+, CD3+CD8+, NK cells and CD19+ are important for us to understand the immune and clincal state, determine the proper treatment protocol in cervical cancer patients.