| Objective:Through the observation of serum cystatin C level in patients with diabetes mellitus complicated with coronary heart disease and diabetic non-coronary heart disease。Analysis of correlation between cystatin C and coronary heart disease, To further explore the relationship between cystatin C and coronary lesion vessels and the severity of, Thus provides certain reference significance for the early diagnosis of coronary heart disease in patients with diabetes mellitus。Methods:Selection in our hospital Heart Institute for coronary artery angiography of 216 cases of diabetic patients as the research object,Requirements through the modified abbreviated MDRD2 equation, Calculation of glomerular filtration rate value(GFR) >90ml/min, According to diagnostic criteria of coronary heart disease of the selected patients were divided into coronary artery smooth group 43 cases,40 cases of coronary atherosclerosis, coronary heart disease group, 143 cases in group。The general clinical data of the three groups (such as gender, age, height, BMI, smoking history, drinking history) for statistical analysis, Collection the study object of cystatin C, total bilirubin, homocysteine, cholesterol, triglyceride, high density lipoprotein cholesterol and fibrinogen determination for statistical analysis, Using the American Heart Disease Association formulated by coronary artery image integral evaluation criteria, with the Gensini integral method, For each branch coronary artery stenosis severity score estimation, According to the results of coronary angiography in coronary heart disease group was divided into three subgroups:Single branch lesion, double vessel lesion group and multi vessel disease group, And compare the general situation and the biochemical indexes between subgroups, Simultaneous analysis of cystatin C and coronary Gensini score levels, And analyze the correlativity, Grouped in diabetic patients, divided into the group of coronary heart disease and non-coronary heart disease, through the Binary Logistic regression, Analysis on risk factors of coronary heart disease。Results:1.Coronary smooth, coronary atherosclerosis, coronary heart disease, between the three groups of serum cystatin C level comparison(0.86±0.17,1.01±0.13,1.13±0.14,P<0.05), A significant difference between the three groups, with the degree of coronary atherosclerosis and cystatin C increased。2. The three group of coronary heart disease, The single branch lesions group, the serum level of Cys-c was 1.01+0.11mg/L, double vessel lesion group, the serum level of Cys-c was 1.12+0.17mg/L, multi vessel disease group the serum level of Cys-c was 1.21+0.09mg/L, Multiple branch lesions group the serum level of Cys-c was significantly higher than that of other disease group (P<0.05)。3.Coronary heart disease between each subgroup, The cystatin -C and Gensini score of coronary heart disease by correlation analysis, Tip is linear positive correlation between cystatin-C level, the higher the score, the Gensini is also higher。4. Multi factor classification of Binary Logistic regression of the whole, found CysC, gender, fibrinogen and coronary heart disease was positively correlated, Where the risk of serum Cys C was 9.541 (P=O.000). Total bilirubin and coronary heart disease was negatively correlated。Conclusion:Exclusion of renal function in patients with coronary heart disease, Serum CysC levels and coronary heart disease occurrence and development are closely related, is a reflection of a biochemical index of coronary atherosclerosis, With the severity of coronary artery stenosis increased, the higher the Gensini score, serum CysC levels with the increase, a linear correlation between them, Serum CysC level is a reflection of confirmed coronary atherosclerosis index, it can indirectly reflect the severity of coronary artery disease, Cystatin C is a risk factor of coronary artery disease, can be used to predict risk of cardiovascular disease。... |
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