Changes Of Sex Hormones In Men Above 40 Years Old And Related Factors

Objective To investigate Changes and related factors of sex hormones in men aboved 40 years old, and analyze similarities and differences between sex hormones in men with metabolically healthy obese(MHO) and in men with metabolic syndrome(MS),for clinical prevention and treatment of metabolic syndrome(MS).Methods Medical data of 3846 men aboved 40 years old in a community of hefei in june 2011 to january 2012 were collected.Detailed medical history were inquired and all the subjects underwent measurements of height, weight, waist and hip circumference and blood pressures,serum levels of blood lipids, blood glucose and Glycated hemoglobin(Hb A1C).The levels of serum total testosterone(TT), estradiol(E2),luteinizing-hormone(LH),follicle-stimulating-hormone(FSH),dehydroepiandroster one sulfate(DHEAS),sex hormone binding globulin(SHBG) were determined by using chemiluminescence methods.Eligible men were screened out according to the relevant diagnostic criteria of obesity and metabolic syndrome(MS)and metabolically healthy obese.Thirty men in the MHO group and thirty men in the MS group were choosed from the eligible men,while thirty men were choosed from the normal as the normal control group.The general data,for example blood pressure,blood glucose,blood lipids and sex hormones of one group were compared with the other two groups.Correlation analysis was used between the general clinical data and sex hormones.Results(1)The levels of Body mass index(BMI),waist circumferenced(WC)and Triglyceride(TG)were significantly different(P<0.05) among MHO group,MS group and normal group.The levels of BMI and WC were significantly higher(P<0.05) in the metabolically healthy obese group and in the metabolic syndrome group than in thenormal control group.TG was significantly lower(P<0.05) in the metabolically healthy obese group than in the metabolic syndrome group.No significant differences of the levels of age,FPG,2-hour postprandial blood glucoseprandial blood glucose(2h PG), Hb A1 C, HDL-C, LDL-C, TC and Waist-to-hip ratio(WHR)could be drawn among the three groups(P>0.05).(2)The concentrations of TT were significantly different(P<0.05) among the three groups.The concentrations of TT showed an ascending trend between MS group,normal group and metabolically healthy obese group.Compared with the MS group,The concentrations of TT in MHO group incresed significantly(P<0.05).No significant differences of the levels of FSH,LH,E2,SHBG and DHEAS could be drawn among the three groups(P>0.05).(3)Age was positively correlated with estradiol(E2)and sex hormone binding globulin(SHBG)(P<0.05),while was not significantly correlated with FSH,LH,TTand DHEAS(P>0.05).TG,Tand LDL-Cwere not significantly correlated with sex hormones(FSH,LH,TT,E2,SHBG,DHEAS)(P>0.05).HDL-C was positively correlated with FSH and LH(P<0.05),while was not significantly correlated with TT,E2,SHBG and DHEAS(P>0.05).Hb A1 C,FBG and PBG were not significantly correlated with FSH,LH,TT,E2,SHBG,DHEAS(P>0.05).Body mass index(BMI) was negatively correlated with follicle-stimulating hormone(FSH)and luteinizing hormone(LH)(P<0.05).BMI was positively correlated with E2 and was not significantly correlated with TT, SHBG, DHEAS(P>0.05).WHR and WC were positively correlated with E2(P<0.05),while were not significantly correlated with FSH, LH, TT, SHBG, DHEAS(P>0.05).Systolic blood pressure(SBP)and Diastolic blood pressure(DBP) were not significantly correlated with sex hormones.(4)The ninety men were divided into three groups(0g/day,0-20 g/day,>20 g/day)by the average of alcohol intake everyday. The concentrations of E2 were significantly different(P<0.05). The concentrations of E2 in the 0-20 g/day group was lowest among the three groups.The concentrations of E2 in >20 g/day was significantly higher than in the 0-20 g/day group(P<0.05). The concentrations of FSH,LH,TT,SHBG,DHEASwere not significantly different(P>0.05)among the three groups.Conclusion(1)Metabolically Healthy Obese(MHO)is a special subset of obesity and shows an intermediate clinical features between normal controls and MS.MHO is possible in a state of the transition between the two.(2)The concentrations of TT in MHO males were significantly higher than in MS males(P<0.05).(3)Age, obesity indices(BMI,WC,WHR,)blood glucose, blood pressure and blood lipids were related with male sex hormones.(4)Alcohol intake had an effect on male sex hormones.