Curarive Effect Of Butyl Phthalide Soft Capsule Combined With Oxiracetam Capsule In Treating Vascular Demential

Objective: To explore and analyze clinical treatment effect of NBP combined with Oxiracetam capsules for vascular dementia(VD).Method: The 90 new VD patients at 3 months to 24 months after the onset of stroke were included in our hospital between January 2012 to May 2014. The cases were diagnosed VD consistented with DSM-IV related to VD criteria and also accompanying with behavioral and psychological symptoms. According to random numbers, all VD patients were divided into A,B,C groups with 30 cases in each. A,B,C groups were treated respectively with NBP, Oxiracetam and NBP combined with Oxiracetam on the basis of conventional treatment on the original disease. A group was given NBP soft capsules, each 0.2g, three times a day; B group was administered oxiracetam capsules, each 0.8g, three times a day; Patients in group C took NBP soft capsules(each 0.2g, three times a day) and oxiracetam capsules(each 0.8g, three times a day); The clinical effect was observed and assessed using mini-mental state examination(MMSE), Hamilton Depression Scale(HAMD), Hachinski Inchemic Score(HIS), ADCS-ADL at 4,12,24 weeks after treatment.Results:1 The scores of MMSE、HAMD、HIS、ADCS-ADL in three groups was not statistically significant before pre-treatment(P > 0.05).2 The MMSE scores in three groups were significantly improved after treatment(P <0.05); The MMSE scores of the group C was significantly higher than A, B groups at 2, 12, 24 weeks after treatement, the difference was statistically significant(P <0.05); Between group A and group B, the difference was not statistically significant after treatment(P > 0.05).3 The HAMD scores in three groups significantly reduced after treatment(P <0.05); The MMSE scores in group C were significantly lower than A and B groups at 2, 12, 24 weeks after treatement, the difference was statistically significant(P <0.05); There was no significant difference between group A and group B after treatment(P > 0.05).4 The HIS scores in three groups significantly reduced after treatment(P <0.05); In group C HIS scores were significantly lower than A and B groups at 2, 12, 24 weeks after treatement, the difference was statistically significant(P <0.05); There was no significant difference between group A and group B after treatment(P > 0.05).5 The ADCS-ADL scores in three groups significantly increased after treatment(P <0.05); The ADCS-ADL scores in group C were significantly higher than A and B groups at 2, 12, 24 weeks after treatement, the difference was statistically significant(P <0.05); There was no significant difference between group A and group B after treatment(P > 0.05).6 Compared with group A and group B, the scores of the MMSE、HAMD、HIS、ADCS-ADL showed early and great changes in group C, the difference was statistically significant(P <0.05); The scores at 24 week after treatment displayed more significant changes than that at 4 and 12 week after treatment and the difference was statistically significant(P <0.05).Conclusion:1 The MMSE scores in three groups after treatment showed significantly increasing trend. Among them the MMSE scores in group C was significantly higher than A, B group at observation time points, which indicated that the effect of the combination therapy was much better than other two drugs alone, effectively enhanced the intellectual level of patients.2 The HAMD scores in three groups after treatment showed significantly decreased. Compared with A, B groups, there was much lower in group C, which indicatied that the effect of the combination therapy was much better than other two drugs alone, effectively improved patients’ depression.3 The HIS scores in three groups after treatment showed significantly decreased. Compared with A, B groups, there was much lower in group C, which indicatied that the effect of the combination therapy was significantly much better than other two drugs alone, effectively improved hypoxic-ischemic brain state for patients.4 The ADCS-ADL scores in three groups after treatment showed significantly increased. Compared with A, B groups, there was much higher in group C, which indicatied that the effect of the combination therapy was significantly much better than other two drugs alone, effectively improved the patients’ daily life capacity.5 Compared with monotherapy, the combination therapy effective appered earlier and were more obvious at 24 week after treatment...