The Correlation Observation Of Carotid Artery Stenosis, Cognitive Dysfunction And High Sensitivity C Reactive Protein

Objective: To study the correlation of carotid artery stenosis, cognitive dysfunction.and high sensitivity C reactive protein(hs-CRP).Methods: 67 patients with carotid artery stenosis were divided into mild carotid artery stenosis group(n=22 cases, artery vessel diameter was reduced<30%), moderate carotid artery stenosis group(n=25 cases, artery vessel diameter was reduced from 30% to 70%) and severe carotid artery stenosis group(n=20 cases, artery vessel diameter was reduced>70%) by using color doppler vascular ultrasound. At the same period, 25 patients without carotid stenosis normal outpatient were selected as control group. The cognitive function of mild carotid artery stenosis group, moderate carotid artery stenosis group and severe carotid artery stenosis group were detected by using the MMSE and Mo CA. The serum hs-CRP expression level of mild carotid artery stenosis group, moderate carotid artery stenosis group, severe carotid artery stenosis group and control group were detected by ELISA.Results:1 The MMSE score, orientation, immediate recall and delayed recall force of moderate carotid artery stenosis group were significantly lower than that of mild carotid artery stenosis group(P<0.05),and the MMSE score, orientation, immediate recall and delayed recall force of severe carotid artery stenosis group were significantly lower than that of moderate carotid artery stenosis group(P<0.05).There was no significant difference about language skills and attention to calculate in each group(P>0.05).2 The MMSE score, the space and executive function, delayed recall, directional force of moderate carotid artery stenosis group were significantly lower than that of mild carotid artery stenosis group(P<0.05), and MMSE score, the space and executive function, delayed recall, directional force of VCIND Vascular cognitive impairment no dementia CT Computed Tomography Hcy Homocysteine同型半胱氨酸FⅦCongenital factorⅦ凝血因子ⅦAS Ankylosing spondylitis强直性脊柱Fg Fibrinogen纤维蛋白原Aββ-amyloid proteinβ-淀粉样蛋白severe carotid artery stenosis group were significantly lower than that of moderate carotid artery stenosis group(P<0.05).There was no significant difference about naming,attention,language and abstract in each group(P>0.05).3 The serum hs-CRP expression levels of each stenosis group were significantly higher than that of control group(P<0.05),and with the carotid stenosis degree aggravating, the serum hs-CRP levels of patients increased significantly(P<0.05).4 67 patiens with carotid stenosis were divided into cognitive dysfunction group(n=37 patients) and non-cognitive dysfunction group(n=30 patients) by Mo CA score, the serum hs-CRP expression levels of cognitive dysfunction group was significantly higher than that of non-recognition dysfunction group(P<0.05).5 The MMSE score and Mo CA scores had a negatively correlated with the degree of carotid stenosis(r1=-0.374, r2=-0.365, P<0.05), and the serum hs-CRP expression levels was positively correlated with the degree of carotid stenosis(r3=0.402, P<0.05).Conclusion: The carotid artery stenosis and hs-CRP had a positive correlation with cognitive dysfunction.