Effect Of Different Eating Periods On The Prognosis Of Patients With Acute Paraquat Poisoning

Objective: 254 cases of patients with acute paraquat poisoning treated in Cangzhou City People’s Hospital since January 2009 to September 2013 were retrospectively analyzed, for the purpose of understanding the impact of different feeding time on the complications and prognosis of patients, providing patients a scientific basis of reasonable feeding time, and enhancing the success rate of treatment.Methods: From January 2009 to September 2013, clinical data of 254 cases of acute paraquat poisoning patients treated in the emergency department of Cangzhou City People’s Hospital were retrospective collected. According to the condition, patients were divided into three groups: 53 light cases, medium-heavy 72 cases, 129 fulminant cases. According to different feeding time, patients in each group were divided into six sections, and the complications and prognosis of patients with different feeding time, including acute lung injury caused / pulmonary fibrosis, acute kidney injury, acute liver injury, and survival were statistically analyzed.Results: All 254 patients were analyzed, found feeding time had no statistical significance for the impact of all kinds of the prognosis of patients(P >0.05). However,all patients were further divided into three groups,we found:In total 53 cases of light patients, the influence on survival rate of different feeding time was statistical significant, P<0.01. The lowest survival rate(80.00%) existed in <12 hours feeding time patients, and the highest survival rate(100.00%) existed in > 44 hours feeding time. Feeding time had no statistical significance for the impact of the prognostic of acute lung injury/pulmonary fibrosis, acute kidney injury, acute liver injury patients(P >0.05). In total 72 cases of medium-heavy patients, the influence on survival rate, acute lung injury/pulmonary fibrosis, acute kidney injury, and patients of different feeding time was statistical significant, P <0.01. The lowest survival rate(50.00%) existed in <12 and 13-20 hours feeding time patients, and the highest survival rate(71.43%) existed in > 44 hours feeding time. The lowest rate(28.57%)of acute lung injury/pulmonary fibrosis complications existed in > 44 hours feeding time and the highest rate(60.00%)existed in 13-20 hours feeding time. The lowest rate(33.33%) of acute kidney injury complications existed in <12 hours feeding time and the highest rate(57.14%)existed in 37-43 hours feeding time. Different feeding times had no statistical significance for the impact of acute liver injury patients(P>0.05). In total 129 cases of fulminant patients, the influence on acute lung injury/pulmonary fibrosis, acute kidney injury, acute liver injury of different feeding time was statistical significant, P <0.01. Patinets with later feeding time had better prognosis relatively. The lowest rate(respectively 74.07%、74.07%、40.74%、66.67%)of acute lung injury/pulmonary fibrosis, acute kidney injury, acute liver injury existed in > 44 hours feeding time, the highest rate(100.00%)of acute lung injury/pulmonary fibrosis, and acute kidney injury existed in <12 and 13-20 hours feeding time, and the highest rate(100.00%)of acute liver injury existed in <12 hours feeding time. Feeding time had no statistical significance for the impact of survival rate(P >0.05). Different feeding time of acute paraquat poisoning patients may have impact on organ injury. In the course of treatment, based on the amount of poison, further classification should be done in time, the degree of severity should be distinguished, and suitable feeding time should be choosen, which may improve the prognosis.Conclusions:1 The overall fatality rate of acute paraquat poisoning patients was high, associated with the amount of poison. The prognosis of fulminant type was poor, medium-heavy type a little better, and light type relatively good.2 Different feeding time of acute paraquat poisoning patients may have impact on organ injury. In the course of treatment, based on the amount of poison, further classification should be done in time, the degree of severity should be distinguished, and suitable feeding time should be choosen, which may improve the prognosis.3 Suitable feeding time of acute paraquat poisoning patients still needs further discussion.