| In recent years, along with the improvement of living standards, Hyperlipidemia and diabetes have become high incidences of the crowd.At present,western medicine mainly through changing the patient’s life style and the use of chemical synthetic medicine to treat hyperlipidemia and diabetes,Although the illness can be controlled in the short term, western medicine can not fundamentally solve the problem. The side effects of long-term use of chemical medicine are obvious, so the use of traditional Chinese medicine to reduce blood fat and to regulate blood sugar is becoming inevitable trend.Xingyujaingtang capsule is a pure traditional Chinese medicine compound preparation for treating diabetes, it is researched and made in traditional Chinese medicine preparation room of Hebei province Cangzhou of integreted traditional and Western medicine.xingyujaingtang capsule consists of huanglian, sangbaipi, zhimu, fuling, zexie, zhishi,shangyao,honghua,chuanniuxi etc and it is made into capsule in modern traditional Chinese medicine preparation process. xingyujiangtang capsule is a pure traditional Chinese medicine compound preparation which is carefully selected in those medicines commonly used in traditional Chinese medicine treatment of diabetes. In this prescription,huanglian is main medicine, its nature is bitter and taste is cold. It is good at clearing damp and hot of spleen, stomach and large intestine.So it is applicable to hyperlipidemia of phlegm turbidity and pixu. Huanglian can also reduce blood sugar levels of the alloxan diabetes and spontaneous diabetes so it can improve the glucose tolerance values.In clinical, it is used to treat weakness, fat body,shortage of breath,xiaogushanji and thirsty to drink more or dizzy, etc,Especially suitable for fueling type 2 diabetes.In order to obtain better clinical curative effect of xingyujiangtang capsule. By studying on the experimental hyperlipidemia in rats and diabetic rats caused by urea with cephalosporins, it provides scientific evidence for hypoglycemic effect and lipid-lowering of xingyujiangtang capsuleThe study mainly includes:1.xingyujaingtang capsule on experimental rats on experimental rat lipid-lowering effect research. 2. xingyujiangtang capsule on experimental rats hypoglycemic effect research. Part 1 xingyujaingtang Capsule on Experimental rats on experimental rat lipid-lowering effect researchObjective:Based on experimental hyperlipidemia and lipid metabolic disturbance model xingyujiangtang capsule pharmacodynamics experiment in rats, xingyujiangtang capsule lipid-lowering effect, provide scientific theory basis for clinical applicationMethod:In SD rats were given fat emulsion to duplicate the model of hyperlipidemia rats, the serum and liver wet weight of rat as experimental index,serum TC, TG, HDL-c and liverindex.The serum TC, TG, HDL-c and liver index data analysis and comparison study of blood stasis, lipid-lowering effect of xingyujiangtang capsule.Results:Model control group rats serum TC, TG, LDL-c was higher than normal control group. Model control group rats serum HDL-c was lower than normal control group. xingyujiangtang capsule(small dose, medium dose and high dose) group TC, TG, LDL-c was lower than those of model control group rats and HDL-c was higher than those of model control group rats The treatment xingyujiangtang capsule group and positive medicine gemfibrozil.group was no significant difference.Conclusions: Xingyujiangtang capsule can significantly reduce hyperlipidemia rats TC, TG, LDL-c, AI and liver coefficient, regulating blood lipid, correct the lipid metabolism disorder, and the chain of urea with cephalosporins to diabetic rats had significantly lower blood sugar. Part 2 Xingyujaingtang capsule on experimental rats hypoglycemic effect researchObjective:Through Diabetic rats model caused by streptozotocin line xingyujiangtang capsule pharmacodynamics experiment, research line xingyujiangtang capsule hypoglycemic effect.Method:Element model of diabetic rats by intraperitoneal injection of STZ, the blood sugar level was measured by the posterior orbital venous blood, and blood glucose values for each group were compared and analyzed, on blood stasis hypoglycemic effect of Jiangtang capsules.Results:Urea with intraperitoneal injection of rats cephalosporins after 72 hours, blood sugar levels were significantly higher than normal control group rats; Model control group rats water after 7 days, the blood sugar level is still higher than normal control group rats; All xingyujiangtang capsule group and positive medicine phenformin group in the rat blood glucose were significantly compared with model control group rats reduced. The treatment line xingyujiangtang capsule group and positive medicine group was no significant difference.Conclusion: Xingyujiangtang capsule has obvious hypoglycemic effect on animal model of hyperglycemia. |
PDF Full Text Request