| Heart disease is one of the most important diseases threatening the lives and health of countless people. Anti-arrhythmic drugs are clinically indispensable. It is the most convenient means of treatment. In the existing anti-arrhythmic drugs, whether it is class â… , class â…¡ or class â…¢, almost all drugs under certain conditions have the proarrhythmic effects. They can cause aggravating existing arrhythmia or induce new arrhythmia. It is difficult for clinicians to predict and evaluate the safety of a drug.In this paper, we use cellular electrophysiology model to simulate the impact of drugs on cardiac myocytes to explain the function of the anti-arrhythmic drugs. We select two typical class â… anti-arrhythmic drugs lidocaine and flecainide, two typical class â…¢ anti-arrhythmic drug amiodarone and d-sotalol as research subjects. The impact of anti-arrhythmic drugs on the cardiac action potential and ion channels are simulated. The results show that in the class â…¢ anti-arrhythmic drugs amiodarone is safer than d-sotalol. D-sotalol potentially has arrhythmogenic effect. Because it extends endocardial cells, M cells, epicardial cell action potential duration heterogeneously, increasing the transmural dispersion of repolarization. The simulation results show that drugs’ effect on endocardial cells, M cells and epicardial cell are different, while M cells are more sensitive to the drug, that may be the target of anti-arrhythmic drugs. |
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