The Use Of Calcium Phosphate/Selenite/Carboxymethyl Chitosan Nanoparticles For Curcumin Delivery In Cancer Treatment

When a combination of two or more compounds exhibit a more potent therapeutic effectthan that of individual compounds at equal concentrations, the effect is described to be asynergistic one. Recently cancer research has focused on improving efficacy andincreasing quality of patients life through reduction of toxicity. In this study, we tested thehypothesis that the bioactive Se ions released from CP/Se/CMC NPs and curcumin (acurcuminoid found in turmeric) loaded within CP/Se/CMC will work in synergism andinhibit the growth of cancer cells. Therefore, CP/Se/CMC NPs with varying amounts of ofSe;0%,3%,6%and10%were synthesized by a coprecipitation method. XRD, FTIR,SEM, and XRF techniques were used to characterize the NPs. When the nanoparticleswere used to deliver curcumin to osteosarcoma, liver cancer cells and breast cancer cells,combination of Se ions and curcumin significantly inhibited cell viability (P<0.05) andcaused induction of cancer cell death in osteosarcoma and liver cancer cell lines as shownby cytotoxicity assay. Statistical analysis revealed no significant toxicity difference withingroups in breast cancer cells. A combination of Se and curcumin proved to be synergisticand/or additive. These data suggests that there is potential for combinational therapy forimprovement of efficacy and reduction in toxicity in, SOS P9607and Hep G2cellstreatment and hence warrants further investigation.