The Oxidative Stress And Effective Factors In Maintenance Dialysis ESED Patients

Objective The main objective of this study was to evaluate the impact of differentdialysis methods on the oxidative stress levels as well as a variety of influencingfactors in CKD5D patients with maintenance dialysis.Methods Serum samples were collected from CKD5D patients and the levels ofhuman super oxide dismnatase (SOD), malondialchehyche (MDA) and glutathioneperoxidase (GSH-Px) were analyzed using ELISA. Statistical analysis was thenperformed based on the laboratory data and clinical information of the patients.Result The levels of oxidative stress in the end-stage kidney disease patients issignificantly higher than the normal levels. We found that the levels of oxidativestress in the end-stage kidney disease patients undertaking two different methods ofdialysis (maintenance hemodialysis v.s. peritoneal dialysis) have significant difference(p<0.05). SOD and MDA levels in hemodialysis patients were significantly lowerthan that in the peritoneal dialysis patients. The regression analysis showed that1) inCKD5D patients, the SOD levels were closely related to whether they tookACEI/ARB, their dialysis history (in months) and gender;2) in hypertensivenephropathy patients, the SOD levels were closely related to their age, gender andwhether statins was used;3) in patients with Type2diabetic nephropathy, the SODlevels were closely related to the dialysis history (in months) and ages of patients;4)in chronic glomerulonephritis patients, the SOD levels were closely related to whetherstatins was used. Conclusions End-stage renal disease patients using the hemodialysis method havehigher oxidative stress levels than patients using the peritoneal dialysis. The oxidativestress levels are closely related to dialysis history (in months), ages and gender.Anemia and inflammation will also significantly increase oxidative stress level.