Analysis Of ATD Treatment On The Serum TRAb With Graves’ Disease

Objective By measuring detection of TRAb level in GD patients peripheral blood andthe change in the diagnosis and treatment of Graves’ disease, and peripheral bloodlymphocyte counts and percentages, to explore the relationship between the pathogenesis,diagnosis, treatment and recurrence of TRAb and GD and its clinical significance.Methods191cases of patients with hyperthyroidism under outpatient treatment andhospitalization in the Endocrinology Department of our hospital were selected from Nov.2012to Sep.2013.29cases are male as well as62cases are female. According to the GDdiagnostic criteria of the Guide of Diagnosis and Treatment of Thyroid Diseases in2008,the GD patients are divided into three groups, including newly diagnosed group (30cases), the alleviated group after anti-thyroid treatment (30cases) and the recurrencegroup (31cases).2The vein blood specimens of all subjects were sampled. Half of thesolution (3ml) was sent to the Clinical Lab of our hospital for determination of LYM,LYM%. The remaining products were sent to the Nuclear Medicine Department fordetermination of TT3, FT3, TT4, FT4, TSH and TRAb.3All the general information,general and auxiliary examination result of all research objects were collected and filledin the questionnaire. All the data were analyzed with SPSS17.0statistics software aftersorting with Excel database. The data were indicated with(x±s) and the enumeration datawere checked with2. t test was used in two independent-samples groups. ANOVAstatistical analysis of the results was used in different groups.Pearson correlation analysiswas adopted among indicators. Probability value (P <0.05)was considered as statisticallysignificant. A P>0.05was taken as showing no significant difference.difference wasstatistically significant.Result1No significant difference in sex and age was observed between the threegroups of GD patients and the control group.2Comparison of serum thyroid hormonesand TRAb level among various groups. The levels of TT3, TT4, FT3, FT4, TRAb in thenewly diagnosed group and recurrence group are higher than those of the alleviated group(P<0.05). The levels of TSH in the newly diagnosed group and recurrence group arelower than those of the alleviated group, while there is no significant difference betweenthe comparison of the newly diagnosed group and recurrence group.3Comparison of thepositive rate of TRAb among various groups. The level of the positive rate of TRAb inthe three groups were statistically significant (P<0.05).4Comparison of FT3、FT4、TSH、TRAb、LYM and LYM%levels before and after treatment between the newly diagnosed group and recurrence group. After one-month’ and two-months’ treatment, the levels ofFT3、FT4、TRAb、LYM and LYM%decreased while the the levels of TSH incresed(P<0.05).5Comparison FT3、FT4、TSH and TRAb level difference between the newlydiagnosed group and recurrence group after treatment. After one-month’s treatmentcompared with pre-treatment, FT3, FT4, TRAb level differences are higher than those of inthe recurrence group, and the degree of change in TSH is lower than the recurrence group(P<0.05). After two month’s treatment compared with pre-treatment, FT3, FT4leveldifferences are higher than those of in the recurrence group, and the degree of change inTSH is lower than the recurrence group (P<0.05), while there is no significant differencebetween the comparison of the two groups about TRAb. After one-month’s treatmentcompared with two-month’s treatment, FT3level difference is higher than that of in therecurrence group,while there is no significant difference between the comparison of thetwo groups about FT4,TSH and TRAb.6Analysis of correlation With TRAb asdependent variable and with FT3, FT4, TSH, LYM, LYM%as independent variable,pearson correlation analysis is carried out. In the newly diagnosed group, TRAb ispositively related to FT3, FT4, LYM, LYM%, while no correlation to TSH. In recurrencegroup, TRAb is positively related to FT3, FT4, LYM, LYM%, while negatively related toTSH.Conclusion1The levels of serum thyroid hormone and TRAb in the GD newlydiagnosed group and recurrence group increased, the level of TRAb in the recurrencegroup is higher than that of the newly diagnosed group. Toexplore TRAb is an importantindicator of Graves’ disease diagnosis and relapse.2Anti-thyroid drugs can modulate theimmunologic function of GD patient, but the effect is very slow, indicating that TRAb isan useful predictor for evaluation the diagnosis and treatment of GD.3AmongGraves’disease patients, TRAb is positively related to FT3, FT4, LYM, LYM%, and ismore positively related to LYM, LYM%; while negatively related to TSH before andafter treatment.