Effects Of Intracoronary Nitroprusside And Tirofiban Injection On The No-reflow Phenomenon During Percutaneous Coronary Intervention

Background: No-reflow phenomenon is a serious complication of percutaneouscoronary intervention (PCI) and associated with poor prognosis. Therefore, effectivelyimproving no-reflow phenomenon is very important.Objective: The aim of this study was to observe the effect of intracoronary injectionsof nitroprusside and tirofiban on no-reflow phenomenon during percutaneouscoronary intervention.Methods: A total of31patients with no reflow were divided into the treatment group(n=12) and the control group (n=19).The treatment group was given intracoronaryinjection of nitroprusside and tirofiban through the micro-catheter immediately whenno-reflow phenomenon occurred, while the control group was given nitroprussideonly. The TIMI flow grade (TIMI) and the corrected TIMI frame count (CTFC) wereused to evaluate the flow of coronary artery. The primary end point was CTFC afteradministrating the drugs.Results: Both the treatment group and the control group showed improvement in TIMIflow grade, and reduction in the corrected TIMI flow frames. No significantdifference was observed in CTFC between the two groups after drug injection(p0.05).Conclusion: Compared with the injection of nitroprusside alone, combinedintra-coronary injection of nitroprusside and tirofiban cannot further improve thetherapeutic effects of no reflow during PCI.