GNB3and AT1R Gene And Inflammation With Uygur Hilit Type Of Essential Hypertension:a Correlation Study

Objective:To explore the association between A1166C polymorphism of Angiotensin Ⅱ type Ⅰ Receptor (AT1R) gene and C825T polymorphism of G protein beta3subunit (GNB3) gene and related indicators of Inflammation and blood rheology and different Hilit types of essential hypertension (EH) in the Uygur nationality of Xinjiang, to explore the pathogenesis of EH From the perspective of Uygur. Methods:The161EH patients (as EH group) and379non-EH patients (as control group) were assigned to different Hilit types. The gene polymorphism was detected by using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Detecting the related indicators of blood biochemical and blood routine. Results:(1) There was statistical difference in the distribution frequencies of genotypes of AT1R A1166C between the EH group and the control group (P=0.008). But There was no statistical difference in the distribution frequencies of genotypes of GNB3C825T between the two groups (P=0.307). The level of BMI、TP、HBDH、UA、WBC、RBCand PLT(et al) is higher in EH group, there was statistically difference (P<0.05).(2) In161EH patients, there was no statistical difference in the distribution frequencies of genotypes of AT1R A1166C between the EH with non-abnormal Sapra and abnormal Sapra (P=0.882). There was statistical difference between the EH with non-abnormal Sapra and control group (P=0.016). There was no statistical difference between the EH with abnormal Sapra and control group (P=0.115). There was statistical difference in the distribution frequencies of genotypes of GNB3C825T between the EH with non-abnormal Sapra and abnormal Sapra(P=0.011).But there were no statistical difference between the EH with non-abnormal Sapra and control group and between the EH with abnormal Sapra and control group(P=0.072,0.106). There was no statistical difference in the level of inflammation and hemorrheology related indexes between the EH with non-abnormal Sapra and abnormal Sapra.(3) In379non-EH patients, there were no statistical difference in the distribution frequencies of genotypes of ATI R A1166C and GNB3C825T between the non-abnormal Sapra and abnormal Sapra (P=0.134,0.190). The non-abnormal Sapra compared with abnormal Sapra the level of WBC, LEM(et al) is higher, but the level of BAS, EOSp, BASp is low, the difference was statistically significant (P<0.05). Conclusion:(1) The pathogeneses of EH with different Hilit types might be different, the AC+CC genotype of AT1R Al166C polymorphism might be associated with EH patients especially with the EH with non-abnormal Sapra.(2)The TT genotype of GNB3C825T polymorphism might not be associated with EH patients and with the EH with non-abnormal Sapra.(3)The AT1R Al166C and GNB3C825T polymorphism might be not associated with different Hilit types.(4) BMI, TP, HBDH, UA,RBCand PLT are the independent risk factors of EH patients.(5) BMI, EOSp,BASp will might be the standards to identify the Hilit types of non-abnormal Sapra and abnormal Sapra.