The Relationship Of Serum Osteocalcin And Peripheral Arterial Disease In Patients With Type2Diabetes Mellitus Between Uygur And Han People

Objective:To investigate the relationship of serum osteocalcin and glucose and lipid metabolism, peripheral arterial disease in type2diabetes patients between Uygur and Han people. Methods:The statistical methods of correlation and regression analysis were applied to explore the relationship of serum osteocalcin and glucose and lipid metabolism, peripheral arterial disease in men and postmenopausal women between264cases of Uygur and217cases of Han patients with type2diabetes mellitus. Results:Using Spearman rank correlation analysis, in Uygur and Han type2diabetes patients, respectively, serum osteocalcin was negatively associated with FPG, HbAlc, TG, and positively associated with HOMA-HBCI, HDL. Further, by sex, in men and postmenopausal women of Han type2diabetes patients, serum osteocalcin was respectively and negatively correlated with FPG, HbAlc. In men and postmenopausal women of Uighur type2diabetes patients, respectively, serum osteocalcin was negatively correlated with FPG, HbA1c, and positively correlated with HOMA-HBCI. The values of P were all less than0.05. By logistic regression analysis after adjusting for age, BMI, smoking, SBP, DBP, duration of DM, FPG, HbA1c, TG, TC, LDL, HDL, Scr, hs-CRP and the medication of hypoglycemic agents, antihypertensive drugs, lipid-lowering drugs and platelet aggregation inhibitor, serum osteocalcin was significantly and negatively related to peripheral arterial disease in men of Uygur patients with type2diabetes mellitus(P<0.05). Conclusion:In type2diabetes patients, serum osteocalcin levels may well predict and evaluate glucose metabolism and lipid metabolism, with a certain clinical reference value. Especially in the Uygur population of male patients, serum osteocalcin levels may be a better clinical predictor of the occurrence of peripheral arterial disease.