The Observation Of Megakaryocytes From Bone Marrow In Myelodysplastic Syndrome And Idiopathic Thrombocytopenic Purpura

Objective:The observing of morbidness megakaryocytes from bone marrow in myelodysplastic syndromes (MDS) and idiopathic thrombocytopenic purpura (ITP), and investigate the significance in the diagnosis of MDS. Methods:classification、comparison and analysis the megakaryocytes from bone marrow in72patients with MDS (including26RCUD and46RCMD) and44ITP patients through the bone marrow aspiration. Results:The detection rates of all morbidness megakaryocytes in refractory cytopenia with unilineage dysplasia (RCUD)、refractory cytopenia with multilineage dysplasia (RCMD) and ITP are higher than those in the control group (P<0.01), especially in RCMD the detection rates of morbidness megakaryocytes was the most highest, significantly higher than RCUD and ITP (P<0.05), although RCUD group has also significantly higher than ITP groups, it has no statistical difference between groups (P>0.05).Regarding the abnormal distribution of morbidness megakaryocytes, the main manifest of dyshaematopoiesis in MDS are mainly by single nuclear megakaryocytes and Micromegakaryocyte, the next is multi-nuclear megakaryocytes, although the MDS group and ITP group were significantly higher than the control group (P<0.01), the detection rate of RCUD and RCMD as well as significantly higher than the ITP group (respectively P<0.05, P<0.01). However, multi-sublobe megakaryocytes mainly in ITP, significantly higher than the MDS and control group (respectively P<0.05, P<0.01), and MDS group compared with controls also showed has a statistically significant (P<0.05). Conclusion: The detection rate of single nuclear megakaryocytes and micromegakaryocyte has the relationship with the degree of dyshaematopoiesis, the observation of the morbidness megakaryocytes have the important meaning to the diagnosis and differential diagnosis of MDS.