| Objective:Based on breathing mobility technical analysis of Lung cancer breathing mobility and its influencing factors, while providing information on the basis for target delineation. Methods:41lung cancer patients with41lesions were scanned the positioning CT under respiratory gating conditions, Stratify the images into10layers:0%-90%,then sketch each lung cancer image, in the base of the end-expiratory image, to outline radiotherapy target of the conventional3D and4D integration respectively. Analysis the change of the two plans clinic tumor volume (CTV),the planning target volume (PTV),breath mobility patterns of lung tumor, and the relationship between it and Volume, the maximum transverse diameter, location, adjacent structure, gender, pathological type. Result:CTV4D volume increase average (9.27±4.13)cm3than CTV3D volume, and PTV4D volume reduce average (33.64±20.46)cm3than PTV3D volume, about PTV3D volume’s11.06%±6.83%,The difference was statistically significant(Z=-5.58;P=0.00),The center and boundary of individuals tumor displacement were obviously different in different directions, and the maximum displacement is in the vertical direction, about (0.55±0.21) cm3,(0.92±0.21) cm3.The lower lobe lung tumors displacement were larger than that of the upper lobe lung, especially significant in the vertical direction, The difference was statistically significant (P=0.01,0.02,0.01).There is no significant correlation between Lung tumors breathing mobility and tumor volume, the maximum diameter. Lung tumors of different near structures and two kinds lung tumors of Scales, glandular were no significant difference in the degree of respiratory motion. Different sex lung cancer patient’s breathing mobility was no significant difference. Conclusion:Lung breathing mobility was individual difference significantly in three dimensions. The using of respiratory gating technology during the CT positioned can reduce the planning target volume and target foreign expansion should be individualized. |
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