Research Of The Relationship Between Abnormal Blood Glucose Fluctuations With Carotid Atherosclerosis In Elderly Population

Objective:To investigate the relationship between abnormal blood glucose fluctuations with atherosclerosis in elderly population.Methods:200patients with pathoglycemia in the department of Endocrinology and Metabolism,changji people’s hospital from December2012to January2014were recruited in this study. All patients were assessed by the continuous glucose monitoring system(CGMS) and the ultrasonography.To collect the general data of the patient, including age, gender, course of disease, smoking history, height, weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), blood biochemical examination, including fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlC), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C). According to the levels of CCA-IMT,200patients were classified into2groups:The normal group of CCA-IMT less than0.9mm (A Group, n=105) Thickening of the group of CCA-IMT be equal or greater than0.9mm(B Group, n=95). Results:(1) A group had lower levels of Course of disease, systolic blood pressure (SBP), fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlC), total cholesterol (TC), LDL-C, standard deviation of blood glucose (SDBG),average blood sugar swings (MAGE),mean absolute difference (MODD) than B group.(P<0.05).There were no differences between two groups of age, gender, course of disease, smoking history, diastolic blood pressure (DBP), Body Mass Index(BMI),(P>0.05);(2):2PG、TG、 LDL-C、SDBG、MAGE、MODD were identified as predictors for CCA-IMT in the Logistic regression analysis.The respective OR value is1.233、2.211、9.548、2.437、1.271、3.842(P<0.05).Conclusion:Glucose fluctuations may contribute to development of atherosclero in aged.