137Cases Food Protein Induced Enterocolitis Syndrome In Neonatal Patients

Objective:To study137cases of neonatal food protein-induced enterocolitis syndrome (Neonatal Food Protein Induced enterocolitis syndrome, NFPIES) clinical manifestations, clinical characteristics, diagnosis, treatment, prognosis, provide a reference for NFPIES of treatment.Methods:In this study, we analysis137NFPIES cases collected during the2007to2012,in line with our inclusion criteria were treated with NFPIES. Analysis of factors including (1) Clinical features including:age and seasonal incidence.(2)The way of delivery.(3) Children factors:gestational age and birth weight;(4) feeding Patterns;(5) concomitant diseases.(6)antibiotics therpy history.(7) Prognosis.(8)Laboratory tests:CRP, stool routine, serum IgE levels were detected.Results:The admitted cases of allergic enterocolitis to our hospital neonatal department showed an increasing trend in2007-2012. Fetal factors:Among137cases:male children is84cases (61%), female children is53cases (39%). Birth weight between2.5-4.0kg is103cases (75%), birth weight between1.0-2.49kg in28cases (20.8%), birth weight greater than4.0kg is6cases (4.2%). Age of onset in1-28days (median16days),14days after the onset of birth63patients (46%).Full-term children is112cases (82%),23cases of preterm children (16.7%), expired births of two cases (1.3%). Among137cases of children with73cases of mixed feeding children (52.8%), artificial feeding children is36cases (26.4%), breastfeeding was28cases (20.8%). Seasonal factors:where born in3、4、5(spring) month of27cases of children (19.7%), birth6、7、8(summer) month of46cases of children (33.5%),9、10、11birth (autumn) cases of38children (27.7%),12、1、2birth (winter) cases of26children (19.1%).Children born by cesarean section96cases (70.1%), children born by vaginal delivery accounted for41cases (29.9%). Parents of either rhinitis, asthma, family history of food allergies which30cases (22%).137 children with C reactive protein values between0.15mg/1-164mg/1(average18.82mg/1).137cases of stool routine in which cases of children with fat droplets were35positive (26%), positive occult blood accounted for23cases (16.8%).Serum allergen-specific IgE antibodies were positive by58cases (42.3%). in which both two and above accounted for36cases (26.3%).Relief of symptoms after unused of antibiotics are36cases as group A,101patients set group B who used antibiotics do not relieve withdrawal symptoms after stoping using antibiotics, the relief time of A is lower than group B. In this study accompanied related diseases108cases (78.8%), in descending order according to the incidence of neonatal anemia, neonatal hyponatremia, hypoglycemia, NEC.Conclusion:1. In recent6years, our new pediatric NFPIES treated patients is on the rise.2. NFPIES in full term, mixed feeding son, cesarean section, occupied the main part of normal birth weight, and a variety of factors, but is usually the result of many factors.3. NFPIES clinical diagnosis of atypical, the diagnosis and differential diagnosis is difficult, not easy to identify with neonatal diseases such as diarrhea, NEC.4. Not company with infectious diseases in NFPIES, antibiotics use extending the duration of symptoms.