| Objective:To investigate the effect on spatial learning and memory ability(SLMA) in young rats of different molar-missing number. Methods:60healthy and young rats were randomly divided into the following six groups:the number of3、6、9and12molars-missing experimental control groups, no molar-missing in anesthetic control group and blank control group. These rats underwent the Morris Water Maze test for six weeks with once perweek after management. Results:There is not significant difference of swimming average escape latency (SAEL) between the number of9and12molars-missing rats groups, but they are significantly higher than other4groups (P <0.001); Comparing the number of6molars-missing group to the number of3molars-missing group, anesthetic control group and blank control group, there is significantly difference of SAEL (P<0.05); Comparing among the number of3molars-missing group, anesthetic group and blank control group, there is not significant difference of SAEL (P>0.05). The tP/tT ratio gradually decreases as the number of molar-missing increasing in four experimental control groups, there is no different between9and12molars-missing inter-group(P>0.05),and there is significant difference among four groups (P<0.05). But the tP/tT ratio dose not show significant difference among the number of3molars-missing group, blank control group and anesthetic group(P>0.05). There is significant difference of tP/tT ratio, comparing other3expeimental control groups to blank control group and anesthetic group(P<0.05). Different number of molar-missing rats in the four groups and anesthesia group and normal group in the before modeling and after management of six weeks, there is no significant differences on changes in weight between the two groups(P>0.05).Conclusions:The cognitive function will be damaged caused by the majority of molar-missing in young rats, while there is not significant effect for the minority of molar-missing. |
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