Effect Of Loading Dose Of Atorvastatin Administrated Perioperative Of PCI On Myocardial Protection

Objective:To study Effect of loading dose of atorvastatin administratedPerioperative of PCI on myocardial protection, and to explore its mechanismMethods: The study was completely randomized, controlled clinical trials, plansselected for elective coronary angiography after PCI with coronary heart disease need60patients (30cases/group), according to the experimenter to give doses ofatorvastatin were randomly divided into conventional dose group20mg/d, loadingdose80mg/d two groups of30people,3days to be undergoing PCI after surgerywere treated with routine therapy with atorvastatin20mg/d, and preoperative andpostoperative12hours respectively, check blood CTNI, CK-MB, HSCRP indicatorscompare preoperative use of statistical methods and postoperative changes inbiochemical parameters were observed loading dose of atorvastatin calcium on PCIperioperative intervention effectsResults and Conclusion:1.Finishing Two groups of patients in hospitalizedbasic clinical information such as: age, gender, height, weight, history of highcholesterol, diabetes mellitus, hypertension, smoking history, history ofcerebrovascular disease, ACEI/ARB, anticoagulants, CCB and coronary arterylesions were not statistically different (P>0.05)2.Preoperative cardiac injury markers and two inflammatory marker levels showed nosignificant difference, PCI retest12hours after cardiac injury markers andinflammatory markers elevated in varying degrees, with the preoperative phase therewas significant difference compared (P <0.05), but loading dose of atorvastatincalcium therapy group CTNI, CK-MB, HS-CRP levels were significantly lower thanthe conventional treatment group, statistically significant (P <0.05).3.Serious adverse reaction mass phenomenon loading dose group, no elevatedtransaminase, rhabdomyolysis, etc. Conclusion:PCI perioperative loading dose of atorvastatin calcium treatmentinterventions can reduce myocardial injury caused by PCI, coronary heart disease,and inflammation, reduce adverse cardiac events after PCI occurs and small adversedrug reactions, safe and effective.