The Relationship Between Plasma C-reactive Protein Level And The Prognosis Of R-Pa On Acute Cerebral Infarction

Objective the purpose of this research is to investigate the influence of CRP onneurologic outcome of the sufferers of acute cerebral infarction under the r-Pa treatment,and discussed whether it is correlated with the death of sufferers after thrombolysis and thehemorrhagic transformation.Method This research collected61acute cerebral infarction cases with treatment ofr-Pa from Yue Yang Second People’s Hospital, Inner Mongolia University Of Science andTechnology First Affiliated Hospital, Guangdong Medical College Affiliated Hospital,Hebei Medical University Second Affiliated Hospital from February to December of2010.The National Institutes of Health Stroke Scale (NIHSS) was adopted to assess the patientswhen they went in the hospital at a scale from4to22points, which suggested that beforethe thrombolysis, no intracranial hemorrhage symbols were found via CT. Based on thedifference of thrombolysis drug doses, patients were divided into two groups, the A Group(0.9mg/Kg) and B Group (0.6mg/Kg). In these two groups, based on the CRP level, theywere further divided into High CRP group (≥3mg/L) and Normal CRP group (＜3mg/L).A statistical analysis would be launched on the24hNIHSS,24hNIHSS score differences,mortality in3months, hemorrhagic transformation ratio, and NIHSS Improvements higheror equivalent to4points after the thrombolysis and baseline.Results Among27cases in A group, there were10cases in High CRP group and17cases in Normal CRP group. Compare the High CRP group and the Normal one: BaselineNIHSS scores demonstrate no statistical significance (P＞0.05).24hNIHSS and24hNHISSscore difference values demonstrate statistical significance (P＜0.05). A comparison onsymptomatic intracranial hemorrhage and mortality in3months revealed no statistical significance (P＞0.05). There were34cases in B group, among wich13cases belonged tothe High CRP group while21cases to the Normal one. Compare the High CRP group andthe Normal one: the Baseline NIHSS,24hNIHSS and24hNIHSS score difference valuesdemonstrate no statistical significance (P＞0.05). The comparison on symptomaticintracranial hemorrhages showed statistical significance (P＜0.05) while the one onmortality in3months did not (P＞0.05). A comparison on baseline NIHSS,24hNIHSS,24hNIHSS score difference value, symptomatic intracranial hemorrhage and mortality in3months of A and B groups did not have statistical significance (P＞0.05). The comparisonbetween SICH in this research and SITS-MOST, NINDS or TTT-AIS had statisticalsignificance (P＜0.05). No statistical significance (P＞0.05) was found in the comparisonbetween the mortality in3months in this research and that of the SITS-MOST, NINDS orTTT-AIS. There was statistical significance (P＜0.05) being found in the comparisonbetween the NIHSS improvement higher than4in24hours and that of the TTT-AIS orNINDS.Conclusions:1. The prognosis of acute cerebral infarction under the r-Pa treatmenthave certain clinical curative effect and have no difference between the low dose and highdose.2. C-reactive protein level have the relationship with the prognosis of r-Pa on acutecerebral infarction.